Results 31 to 40 of about 135,006 (287)

Early life imprints the hierarchy of T cell clone sizes [PDF]

eLife 2020 9:e61639, 2020
The adaptive immune system responds to pathogens by selecting clones of cells with specific receptors. While clonal selection in response to particular antigens has been studied in detail, it is unknown how a lifetime of exposures to many antigens collectively shape the immune repertoire.
arxiv   +1 more source

A case report of neonatal alloimmune thrombocytopenic purpura: the importance of correct diagnosis for future pregnancies

São Paulo Medical Journal
CONTEXT: Neonatal alloimmune thrombocytopenic purpura (NAITP) is a neonatal disorder characterized by maternal alloimmunization against fetal platelet antigens inherited from the father.
Rita Fontão-Wendel, Silvano Wendel, Vicente Odone, Jorge David Carneiro, Leandra Silva, Eduardo Isfer   +5 more
doaj   +1 more source

Phagocytosis of platelets opsonized with differently glycosylated anti-HLA hIgG1 by monocyte-derived macrophages

Platelets, 2023
Immune-mediated platelet refractoriness (PR) remains a significant problem in the setting of platelet transfusion and is predominantly caused by the presence of alloantibodies directed against class I human leukocyte antigens (HLA). Opsonization of donor
Thijs L. J. van Osch, Juulke Steuten, Jan Nouta, Carolien A. M. Koeleman, Arthur E. H. Bentlage, Sebastiaan Heidt, Arend Mulder, Jan Voorberg, S. Marieke van Ham, Manfred Wuhrer, Anja ten Brinke, Gestur Vidarsson   +11 more
doaj   +1 more source

Three-dimensional Multiscale Model of Deformable Platelets Adhesion to Vessel Wall in Blood Flow [PDF]

, 2013
When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering and rolling on the injured endothelium is a critical initial step in blood clot formation.
arxiv   +1 more source

Microfluidic approach to genotyping human platelet antigens

IET Nanobiotechnology, 2012
Centralised laboratories routinely determine blood types by serological and molecular methods. Current practices have limitations in terms of cost, time and accessibility. Miniaturised microfluidic platforms offer an alternative to conventional genotyping methods, since they consume fewer reagents, provide faster analysis and allow for complete ...
Gregory A. Denomme, Dammika P. Manage, Christopher J. Backhouse, Alexey Atrazhev, Jason P. Acker, Chong-U Lim   +5 more
openaire   +3 more sources

The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/hepatitis C virus coinfected patients

Revista da Sociedade Brasileira de Medicina Tropical, 2015
INTRODUCTION:Hepatic fibrosis progression in patients with chronic hepatitis C virus infections has been associated with viral and host factors, including genetic polymorphisms.
Natália Picelli, Aline Aki Tanikawa, Rejane Maria Tommasini Grotto, Giovanni Faria Silva, Alexandre Naime Barbosa, Adriana Camargo Ferrasi, Liciana Vaz de Arruda Silveira, Maria Inês de Moura Campos Pardini   +7 more
doaj   +1 more source

Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report

Case Reports in Medicine, 2013
Posttransfusion purpura (PTP) is an uncommon, but potentially fatal, transfusion reaction characterized by profound thrombocytopenia and bleeding. PTP is caused by alloimmunization to human platelet specific antigens following blood component transfusion.
O. P. Arewa, S. Nahirniak, G. Clarke
doaj   +1 more source

Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses [PDF]

, 2015
Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and re-infect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA) and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies.
arxiv   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

AVIDa-hIL6: A Large-Scale VHH Dataset Produced from an Immunized Alpaca for Predicting Antigen-Antibody Interactions [PDF]

arXiv, 2023
Antibodies have become an important class of therapeutic agents to treat human diseases. To accelerate therapeutic antibody discovery, computational methods, especially machine learning, have attracted considerable interest for predicting specific interactions between antibody candidates and target antigens such as viruses and bacteria.
arxiv