Results 31 to 40 of about 1,500,945 (336)

Tryptophan metabolism in bipolar disorder

European Psychiatry, 2022
Introduction Immune mediated inflammatory processes are involved in the aetiopathogenesis of bipolar disorder (BD) and weight associated comorbidities. Tryptophan breakdown via indoleamine 2,3-dioxygenase-1 (IDO-1) along the kynurenine axis concomitant ...
F. Fellendorf, M. Platzer, A. Birner, R. Queissner, S. Bengesser, M. Lenger, A. Maget, A. Tmava-Berisha, N. Dalkner, D. Fuchs, J. Gostner, E. Reininghaus   +11 more
doaj   +1 more source

Sinomenine ameliorates rheumatoid arthritis by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation.

Science Bulletin, 2023
Gut microbiota dysbiosis is associated with the development of rheumatoid arthritis (RA). Sinomenine (SIN) is an effective immunosuppressive and anti-inflammatory drug used for treating RA, but how SIN regulates gut microbiota to alleviate RA remains ...
Zheng‐Meng Jiang, Su-Ling Zeng, Tian-Qing Huang, Yang Lin, Fang Wang, Xing-Jiao Gao, Jing Li, Ping Li, Ehu Liu   +8 more
semanticscholar   +1 more source

Tryptophan Metabolism and Gut-Brain Homeostasis

International Journal of Molecular Sciences, 2021
Tryptophan is an essential amino acid critical for protein synthesis in humans that has emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the neurotransmitter serotonin, which is vital for the processing of emotional ...
W. Roth, Kimia Zadeh, Rushi Vekariya, Yong Ge, M. Mohamadzadeh   +4 more
semanticscholar   +1 more source

Tryptophan Metabolism in Alcoholism [PDF]

Nutrition Research Reviews, 1999
Studies of tryptophan (Trp) metabolism in relation to the serotonin status in alcoholism are of 2 types: (1) those related to the pharmacological effects of ethanol; (2) those concerning the serotonin status in the absence of alcohol intake. In experimental animals, acute and chronic ethanol administration and subsequent withdrawal exert a variety of ...
openaire   +3 more sources

The Kynurenine Pathway and Indole Pathway in Tryptophan Metabolism Influence Tumor Progression. [PDF]

Cancer Med
Tryptophan (Trp), an essential amino acid, is solely acquired through dietary intake. It is vital for protein biosynthesis and acts as a precursor for numerous key bioactive compounds.
Lu Z, Zhang C, Zhang J, Su W, Wang G, Wang Z.   +5 more
europepmc   +2 more sources

Tryptophan Metabolism in Central Nervous System Diseases: Pathophysiology and Potential Therapeutic Strategies

Aging and Disease, 2023
The metabolism of L-tryptophan (TRP) regulates homeostasis, immunity, and neuronal function. Altered TRP metabolism has been implicated in the pathophysiology of various diseases of the central nervous system. TRP is metabolized through two main pathways,
Yinrou Huang, Mengke Zhao, Xuemei Chen, Ruoyu Zhang, Anh Le, Michael Hong, Yufei Zhang, Lin Jia, Weidong Zang, Chao Jiang, Junmin Wang, Xiaochong Fan, Jian Wang   +12 more
semanticscholar   +1 more source

Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]

, 2010
Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
Berfelo, M. W., Hulsman, J. A. R. J., Majoie, H. J. M., Myint, A., Rijkers, K., Schwarz, M., Vles, J. S. H.   +6 more
core   +13 more sources

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.

Cell Host and Microbe, 2018
The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or derived from the transformation of environmental or host molecules. Among the array of metabolites at
A. Agus, J. Planchais, H. Sokol
semanticscholar   +1 more source

An expanding range of targets for kynurenine metabolites of tryptophan [PDF]

, 2013
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail, Stone, Trevor W., Stoy, Nicholas   +2 more
core   +1 more source

Tryptophan Metabolism in Depression: A Narrative Review with a Focus on Serotonin and Kynurenine Pathways

International Journal of Molecular Sciences, 2022
Depression is a common and serious disorder, characterized by symptoms like anhedonia, lack of energy, sad mood, low appetite, and sleep disturbances.
A. Correia, N. Vale
semanticscholar   +1 more source