Results 41 to 50 of about 59,785 (337)

Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkers

Nature Cell Biology, 2008
Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain microvascular endothelial cells.
J. Skog, T. Wurdinger, Sjoerd van Rijn, D. Meijer, Laura Gainche, M. Sena-Esteves, W. Curry, R. Carter, Anna M. Krichevsky, X. Breakefield   +9 more
semanticscholar   +1 more source

EVALUATION OF MICROVESICLES FORMED BY NATURAL KILLER (NK) CELLS USING FLOW CYTOMETRY

Медицинская иммунология, 2018
As a result of activation and/or apoptosis, the cells can form microvesicles (MV) from 100 nm up to 1000 nm in size. Nowadays, the attention is being increasingly focused on dynamic detection and evaluation of leukocyte-derived microvesicles by their ...
V. A. Mikhailova, K. L. Belyakova, L. P. Vyazmina, A. R. Sheveleva, S. A. Selkov, D. I. Sokolov   +5 more
doaj   +1 more source

Enhanced Antioxidant Effects of the Anti-Inflammatory Compound Probucol When Released from Mesoporous Silica Particles

Pharmaceutics, 2022
Brain endothelial cells mediate the function and integrity of the blood brain barrier (BBB) by restricting its permeability and exposure to potential toxins.
Michael Lau, Benjamin Sealy, Valery Combes, Marco Morsch, Alfonso E. Garcia-Bennett   +4 more
doaj   +1 more source

Whole-body heat stress and exercise stimulate the appearance of platelet microvesicles in plasma with limited influence of vascular shear stress [PDF]

, 2017
Intense, large muscle mass exercise increases circulating microvesicles, but our understanding of microvesicle dynamics and mechanisms inducing their release remains limited.
Chiesa, Scott T., González-Alonso, José, Kalsi, Kameljit K., Rakobowchuk, Mark, Trangmar, Steven J., Wilhelm, Eurico N.   +5 more
core   +5 more sources

Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation [PDF]

, 2015
We previously reported that high levels of tissue factor (TF) can induce cellular apoptosis in endothelial. In this study, TF-mediated mechanisms of induction of apoptosis were explored.
Collier, Mary E. W., ElKeeb, Azza M., Ettelaie, Camille, Maraveyas, Anthony   +3 more
core   +1 more source

Microvesicles and Microvesicle-Associated microRNAs Reflect Glioblastoma Regression: Microvesicle-Associated miR-625-5p Has Biomarker Potential

International Journal of Molecular Sciences, 2022
Glioblastoma (GB) is the most aggressive and recurrent form of brain cancer in adults. We hypothesized that the identification of biomarkers such as certain microRNAs (miRNAs) and the circulating microvesicles (MVs) that transport them could be key to establishing GB progression, recurrence and therapeutic response.
Natalia Simionescu, Miruna Nemecz, Anca-Roxana Petrovici, Ioan Sebastian Nechifor, Razvan-Cristian Buga, Marius Gabriel Dabija, Lucian Eva, Adriana Georgescu   +7 more
openaire   +2 more sources

Levels of activated platelet-derived microvesicles in patients with soft tissue sarcoma correlate with an increased risk of venous thromboembolism

BMC Cancer, 2017
Background Microvesicles are small vesicles expressing specific antigens from their cells of origin. Elevated levels of microvesicles have been shown to be associated with coagulation disorders as well as with different types of malignancies.
A. Fricke, P. V. Ullrich, A. F. V. Cimniak, C. Becherer, M. Follo, J. Heinz, J. Scholber, G. W. Herget, O. Hauschild, U. A. Wittel, G. B. Stark, H. Bannasch, D. Braig, S. U. Eisenhardt   +13 more
doaj   +1 more source

Microvesicles from Human Immortalized Cell Lines of Endothelial Progenitor Cells and Mesenchymal Stem/Stromal Cells of Adipose Tissue Origin as Carriers of Bioactive Factors Facilitating Angiogenesis

Stem Cells International, 2020
Endothelial progenitor cells (EPCs) and mesenchymal stem/stromal cells (MSCs) are associated with maintaining tissue homeostasis and tissue repair. Both types of cells contribute to tissue regeneration through the secretion of trophic factors (alone or ...
Agnieszka Krawczenko, Aleksandra Bielawska-Pohl, Maria Paprocka, Honorata Kraskiewicz, Agnieszka Szyposzynska, Elżbieta Wojdat, Aleksandra Klimczak   +6 more
doaj   +1 more source

Analysis of the potential of cancer cell lines to release tissue factor-containing microvesicles: correlation with tissue factor and PAR2 expression [PDF]

, 2016
BackgroundDespite the association of cancer-derived circulating tissue factor (TF)-containing microvesicles and hypercoagulable state, correlations with the incidence of thrombosis remain unclear.MethodsIn this study the upregulation of TF release upon ...
A Bharthuar, A Delluc, A Falanga, A Rank, A Rank, AA Khorana, AA Khorana, Anthony Maraveyas, AS Wolberg, BA Lwaleed, C Ettelaie, C Ettelaie, C Hernández, C Sapet, Camille Ettelaie, E Camerer, E Campello, E Cocco, ES Breimo, F Doormaal van, F Langer, GW Tormoen, H Kothari, I Pabinger, J Ahamed, J Thaler, J Thaler, J Thaler, JA Bastarache, JE Geddings, JH Morrissey, John Greenman, K Haubold, KG Livak, L Hu, LV Rao, M Davila, Mary EW Collier, ME Collier, ME Collier, ME Collier, ME Collier, ME Tesselaar, ML Rand, N Satta, N Tavoosi, Naima E. Benelhaj, NS Key, P Bucciarelli, R Flaumenhaft, RI Kushak, S Butenas, SJ Compton, SK Dasgupta, Sophie Featherby, T Kawamoto, V Combes, W Ruf   +57 more
core   +2 more sources

Microvesicles as Mediators of Tissue Regeneration [PDF]

Translational Research, 2014
The use of stem cells in the treatment of various diseases and injuries has received increasing interest during the past decade. Injected stem cells, such as mesenchymal stem cells, stimulate tissue repair largely through the secretion of soluble factors that regulate various processes of tissue regeneration, including inflammatory responses, apoptosis,
Nobuaki Kikyo, Keith Sabin
openaire   +3 more sources