Results 1 to 10 of about 8,374 (117)

Rottlerin Stimulates Exosome/Microvesicle Release Via the Increase of Ceramide Levels Mediated by Ampk in an In Vitro Model of Intracellular Lipid Accumulation

Biomedicines, 2022
Exosomes/microvesicles originate from multivesicular bodies that allow the secretion of endolysosome components out of the cell. In the present work, we investigated the effects of rottlerin, a polyphenol, on exosome/microvesicle secretion in a model of ...
Rebeca Busto, OSCAR Pastor, Javier Martinez-Botas   +2 more
exaly   +3 more sources

Response of the tegument of Fasciola hepatica to infection and immunization sera in vitro [PDF]

Parasitology
The migratory phase is a critical time for Fasciola hepatica as it must locate, penetrate and migrate through the alimentary tract to the liver parenchyma whilst under attack from the host immune response.
Clive E. Bennett, Adam P.S. Bennett, Robert E.B. Hanna, Mark W. Robinson   +3 more
doaj   +2 more sources

Tp47-Induced Monocyte-Derived Microvesicles Promote the Adherence of THP-1 Cells to Human Umbilical Vein Endothelial Cells via an ERK1/2–NF-κB Signaling Cascade

Microbiology Spectrum, 2023
The Treponema pallidum membrane protein Tp47 induces immunocyte adherence to vascular cells and contributes to vascular inflammation. However, it is unclear whether microvesicles are functional inflammatory mediators between vascular cells and ...
M. Wang, J.-W. Xie, Y.-W. Zheng, X.-T. Wang, D.-Y. Yi, Y. Lin, M.-L. Tong, L.-R. Lin   +7 more
doaj   +1 more source

M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors

Journal of Nanobiotechnology, 2021
Cancer cells and cancer stem cells (CSCs) are the major players of cancer malignancy and metastasis, but they are extremely difficult to access. Inspired by the vital role of macrophages and microvesicle-mediated cell–cell communication in tumors, we ...
Yuqi Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Yao Wu, Jiaoying Wang, Siling Wang, Yaping Li, Zhiwen Zhang   +9 more
doaj   +1 more source

A Comparative Proteomic Analysis of Extracellular Vesicles Associated With Lipotoxicity

Frontiers in Cell and Developmental Biology, 2021
Extracellular vesicles (EVs) are emerging mediators of intercellular communication in nonalcoholic steatohepatitis (NASH). Palmitate, a lipotoxic saturated fatty acid, activates hepatocellular endoplasmic reticulum stress, which has been demonstrated to ...
Yasuhiko Nakao, Yasuhiko Nakao, Masanori Fukushima, Masanori Fukushima, Amy S. Mauer, Chieh-Yu Liao, Anya Ferris, Anya Ferris, Debanjali Dasgupta, Debanjali Dasgupta, Carrie Jo Heppelmann, Patrick M. Vanderboom, Patrick M. Vanderboom, Mayank Saraswat, Mayank Saraswat, Mayank Saraswat, Akhilesh Pandey, Akhilesh Pandey, Akhilesh Pandey, Akhilesh Pandey, K. Sreekumaran Nair, Alina M. Allen, Kazuhiko Nakao, Harmeet Malhi   +23 more
doaj   +1 more source

Effect of Mesenchymal Stem Cell-derived Microvesicles on Megakaryocytic Differentiation of CD34+ Hematopoietic Stem Cells [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: Mesenchymal stem cells (MSCs) release hematopoietic cytokines, growth factors, and Microvesicles (MVs) supporting the hematopoietic stem cells (HSCs).
Sara Aqmasheh, Karim Shamsasenjan, Elham Khalaf Adeli, Aliakbar Movassaghpourakbari, Parvin Akbarzadehlaleh, Davod Pashoutan Sarvar, Hamzeh Timari   +6 more
doaj   +1 more source

Vesiculation of Red Blood Cells in the Blood Bank: A Multi-Omics Approach towards Identification of Causes and Consequences

Proteomes, 2020
Microvesicle generation is an integral part of the aging process of red blood cells in vivo and in vitro. Extensive vesiculation impairs function and survival of red blood cells after transfusion, and microvesicles contribute to transfusion reactions ...
Joames K. Freitas Leal, Edwin Lasonder, Vikram Sharma, Jürgen Schiller, Giuseppina Fanelli, Sara Rinalducci, Roland Brock, Giel Bosman   +7 more
doaj   +1 more source

RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls

BMC Cancer, 2012
Background RNA from exosomes and other microvesicles contain transcripts of tumour origin. In this study we sought to identify biomarkers of glioblastoma multiforme in microvesicle RNA from serum of affected patients.
Noerholm Mikkel, Balaj Leonora, Limperg Tobias, Salehi Afshin, Zhu Lin, Hochberg Fred H, Breakefield Xandra O, Carter Bob S, Skog Johan   +8 more
doaj   +1 more source

Characterizing Extracellular Vesicles and Their Diverse RNA Contents

Frontiers in Genetics, 2020
Cells release nanometer-scale, lipid bilayer-enclosed biomolecular packages (extracellular vesicles; EVs) into their surrounding environment. EVs are hypothesized to be intercellular communication agents that regulate physiological states by transporting
Eren M. Veziroglu, Eren M. Veziroglu, George I. Mias, George I. Mias   +3 more
doaj   +1 more source

Circulating Thrombomodulin: Release Mechanisms, Measurements, and Levels in Diseases and Medical Procedures

TH Open, 2022
Thrombomodulin (TM) is a type-I transmembrane protein that is mainly expressed on endothelial cells and plays important roles in many biological processes. Circulating TM of different forms are also present in biofluids, such as blood and urine.
Mallorie Boron, Tiffany Hauzer-Martin, Joseph Keil, Xue-Long Sun   +3 more
doaj   +1 more source