Results 41 to 50 of about 2,292,477 (411)
RNA interference and Register Machines (extended abstract) [PDF]
EPTCS 100, 2012, pp. 107-112, 2012 RNA interference (RNAi) is a mechanism whereby small RNAs (siRNAs) directly control gene expression without assistance from proteins. This mechanism consists of interactions between RNAs and small RNAs both of which may be single or double stranded. The target of the mechanism is mRNA to be degraded or aberrated, while the initiator is double stranded ...
arxiv +1 more source
Assessment of RNAi-induced silencing in banana (Musa spp.) [PDF]
, 2015 In plants, RNA- based gene silencing mediated by small RNAs functions at the transcriptional or post-transcriptional level to negatively regulate target genes, repetitive sequences, viral RNAs and/or transposon elements.
Cammue, B.P.A. +6 more
core +1 more source
Pseudogenes, RNAs and new reproducibility norms
eLife, 2020 The partial success of a study to reproduce experiments that linked pseudogenes and cancer proves that understanding RNA networks is more complicated than expected.
George A Calin
doaj +1 more source
RNA interference is mediated by 21- and 22-nucleotide RNAs.
Genes & Development, 2001 Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 21- and 22-nt RNA fragments are the sequence-
Sayda M. Elbashir +2 more
semanticscholar +1 more source
Structural insights into RNA processing by the human RISC-loading complex. [PDF]
, 2009 Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC).
AD Haase +41 more
core +2 more sources
Quantitative analysis of competition in post-transcriptional regulation reveals a novel signature in target expression variation [PDF]
Biophysical Journal, 104 (4), 951-958 (2013), 2012 When small RNAs are loaded onto Argonaute proteins they can form the RNA-induced silencing complexes (RISCs), which mediate RNA interference. RISC-formation is dependent on a shared pool of Argonaute proteins and RISC loading factors, and is thus susceptible to competition among small RNAs for loading.
arxiv +1 more source
A fruitful fly forward : the role of the fly in drug discovery for neurodegeneration [PDF]
, 2014 AD, Alzheimer’s disease; APP, amyloid precursor protein; BBB, blood brain barrier; GFP, green fluorescent protein; HTS, high-throughput screening; HD, Huntington’s disease; LB, Lewy bodies; PD, Parkinson’s disease; PolyQ, Polyglutamine; RNAi, RNA ...
Briffa, Michelle +2 more
core +1 more source
Modeling and Optimization of Genetic Screens via RNA Interference and FACS [PDF]
Prob. Eng. Inf. Sci. 29 (2015) 131-145, 2014 We study mathematically a method for discovering which gene is related to a cell phenotype of interest. The method is based on RNA interference -- a molecular process for gene deactivation -- and on coupling the phenotype with fluorescence in a FACS machine. A small number of candidate genes are thus isolated, and then tested individually.
arxiv +1 more source
Virus-derived DNA drives mosquito vector tolerance to arboviral infection
Nature Communications, 2016 Mosquitoes tolerate long-lasting viral infections, which makes them efficient vectors for human viral diseases. Here, the authors show that the tolerance of Aedesmosquitoes to infection with dengue or chikungunya viruses depends on the production of ...
Bertsy Goic +10 more
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Mathematical model of plant-virus interactions mediated by RNA interference [PDF]
J. Theor. Biol. 403, 129-142 (2016), 2016 Cross-protection, which refers to a process whereby artificially inoculating a plant with a mild strain provides protection against a more aggressive isolate of the virus, is known to be an effective tool of disease control in plants. In this paper we derive and analyse a new mathematical model of the interactions between two competing viruses with ...
arxiv +1 more source