Results 41 to 50 of about 1,500,945 (336)
Microorganisms, 2021 Akkermansia muciniphila, a potential probiotic, has been proven to lessen the effects of several diseases. As established, the relative abundance of Akkermansia is positively correlated with tryptophan metabolism.
Jia Yin +7 more
doaj +1 more source
Translating Metabolic Reprogramming into New Targets for Kidney Cancer. [PDF]
, 2017 In the age of bioinformatics and with the advent of high-powered computation over the past decade or so the landscape of biomedical research has become radically altered.
Abu Aboud, Omran, Weiss, Robert H
core +1 more source
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer
Nature Communications, 2022 Indoleamine 2,3 dioxygenase 1 (IDO1) is an attractive target for cancer immunotherapy. However, IDO1 inhibitors have shown disappointing therapeutic efficacy in clinical trials, mainly because of the activation of the aryl hydrocarbon receptor (AhR ...
Dongni Shi +17 more
semanticscholar +1 more source
Nature Communications, 2022 Honeybees are highly social insects with a rich behavioral repertoire and are a versatile model for neurobiological research. Their gut microbiota comprises a limited number of host-restricted bacterial phylotypes that are important for honeybee health ...
Zijing Zhang +5 more
semanticscholar +1 more source
Metformin reprograms tryptophan metabolism to stimulate CD8+ T cell function in colorectal cancer.
Cancer Research, 2023 Colorectal carcinogenesis coincides with immune cell dysfunction. Metformin has been reported to play a role in stimulating anti-tumor immunity, suggesting it could be used to overcome immunosuppression in colorectal cancer (CRC).
Xiaowen Huang +12 more
semanticscholar +1 more source
The Role of Tryptophan Metabolism in Alzheimer’s Disease
Brain Science, 2023 The need to identify new potentially druggable biochemical mechanisms for Alzheimer’s disease (AD) is an ongoing priority. The therapeutic limitations of amyloid-based approaches are further motivating this search.
Karl Savonije, D. Weaver
semanticscholar +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Tryptophan is metabolized by microorganisms into various indole derivatives that have been proven to alleviate diseases and promote human health. Lactic acid bacteria (LAB) are a broad microbial concept, some of which have been developed as probiotics ...
Tong Pan +8 more
semanticscholar +1 more source
Nutrients, 2023 Evidence is emerging for the role of intestinal tryptophan metabolism in the development of inflammatory bowel disease (IBD). In order to identify the role of altered intestinal tryptophan metabolism in IBD pathogenesis, a meta-analysis of the ...
Sha Wang +4 more
semanticscholar +1 more source
Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease
Experimental Gerontology, 2023 The intricate interplay between gut microbiota and the host is pivotal in maintaining homeostasis and health. Dietary tryptophan (TRP) metabolism initiates a cascade of essential endogenous metabolites, including kynurenine, kynurenic acid, serotonin ...
Sonu Kumar Gupta +5 more
semanticscholar +1 more source
Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity
Microbiome, 2022 Background Dysregulation of gut microbiota-associated tryptophan metabolism has been observed in patients with multiple sclerosis. However, defining direct mechanistic links between this apparent metabolic rewiring and individual constituents of the gut ...
T. Montgomery +8 more
semanticscholar +1 more source