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Translational control of cyclins [PDF]

open access: yesCell Division, 2011
Regulation of cyclin levels is important for many cell cycle-related processes and can occur at several different steps of gene expression. Translational regulation of cyclins, which occurs by a variety of regulatory mechanisms, permits a prompt response
Lai Ming-Chih, Tarn Woan-Yuh
doaj   +5 more sources

Identification of Arabidopsis meiotic cyclins reveals functional diversification among plant cyclin genes. [PDF]

open access: yesPLoS Genetics, 2013
Meiosis is a modified cell division in which a single S-phase is followed by two rounds of chromosome segregation resulting in the production of haploid gametes.
Petra Bulankova   +3 more
doaj   +2 more sources

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. [PDF]

open access: greenMolecular and Cellular Biology, 1994
Conditional overexpression of human cyclins B1, D1, and E was accomplished by using a synthetic cDNA expression system based on the Escherichia coli tetracycline repressor. After induction of these cyclins in asynchronous Rat-1 fibroblasts, a decrease in
D. Resnitzky   +3 more
semanticscholar   +2 more sources

Expression Dynamics and Genetic Compensation of Cell Cycle Paralogues in Saccharomyces cerevisiae [PDF]

open access: yesCells
Cell cycle progression of the yeast Saccharomyces cerevisiae is largely driven by the expression of cyclins, which in turn bind the cyclin-dependent kinase CDK1 providing specificity.
Gabriele Schreiber   +5 more
doaj   +2 more sources

Cell cyclins: triggering elements of cancer or not?

open access: yesWorld Journal of Surgical Oncology, 2010
Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the
Pateras Ioannis   +6 more
doaj   +2 more sources

The Less Known Cyclins—Uncovered

open access: yesApplied Sciences, 2021
Cyclins belong to a group of proteins that are cyclically produced and destructed in a cell. Cyclins are a family of proteins that are a key component of the cell cycle regulating system, which level of expression depends on the phase of the cycle ...
Agnieszka Żuryń   +4 more
doaj   +1 more source

In vivo assessment of simultaneous G1 cyclins silencing by a tumor-specific bidirectional promoter on the mammary tumor in nude mice

open access: yesFrontiers in Veterinary Science, 2022
Dysregulation of G1 cyclins (cyclins D1 A and E) expression contributes to the loss of standard cell cycle control during tumorigenesis. This study aims to evaluate the inhibitory effect of G1 cyclins in nude mice.
Gholamreza Mesbah   +6 more
doaj   +1 more source

Viral cyclins mediate separate phases of infection by integrating functions of distinct mammalian cyclins. [PDF]

open access: yesPLoS Pathogens, 2012
Gammaherpesvirus cyclins have expanded biochemical features relative to mammalian cyclins, and promote infection and pathogenesis including acute lung infection, viral persistence, and reactivation from latency.
Katherine S Lee   +5 more
doaj   +1 more source

Prediction of Cyclin Protein Using Two-Step Feature Selection Technique

open access: yesIEEE Access, 2020
Cyclins are a family of proteins that regulate the cell cycle by activating cyclin-dependent kinases or a group of enzymes required in the cell cycle. Constructing a model to classify Cyclins is of importance to understand their function. It is urgent to
Jia-Nan Sun   +6 more
doaj   +1 more source

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma

open access: yesCells, 2022
Pancreatic cancer is a leading cause of cancer mortality and is projected to become the second-most common cause of cancer mortality in the next decade. While gene-wide association studies and next generation sequencing analyses have identified molecular
Cristina Di Giorgio   +16 more
doaj   +1 more source

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