Results 1 to 10 of about 280,511 (396)
Immunoglobulin heavy-chain-associated amyloidosis. [PDF]
Proceedings of the National Academy of Sciences, 1990 Immunoglobulin- or multiple myeloma-associated amyloidosis has been distinguished by the tissue deposition of Congophilic, fibrillar protein consisting of light chains or light-chain fragments (AL amyloidosis). We now report the isolation and characterization of another form of immunoglobulin-associated amyloid obtained from a patient who had extensive
Alan Solomon +2 more
openaire +3 more sources
Diagnostic Pathology, 2022 Background Mu heavy chain disease is a rare lymphoid neoplasm characterized by vacuolated bone marrow plasma cells and secretion of defective mu immunoglobulin heavy chains. The biological basis of mu heavy chain disease is poorly understood.
Vandana Baloda +9 more
doaj +1 more source
Spin chain on a metallic surface: Dissipation-induced order vs. Kondo entanglement [PDF]
Phys. Rev. B 106, L161103 (2022), 2022 We explore the physics of a spin-1/2 Heisenberg chain with Kondo interaction, $J_k$, to a two-dimensional electron gas. At weak $J_k$ the problem maps onto a Heisenberg chain locally coupled to a dissipative Ohmic bath. At the decoupled fixed point, the dissipation is a marginally relevant perturbation and drives long-range antiferromagnetic order ...
arxiv +1 more source
Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment. [PDF]
PLoS ONE, 2018 Recent evidence indicates the presence of macrophage subpopulations that express the TCRαβ in chronic inflammatory diseases such as tuberculosis and atherosclerosis and in the tumor microenvironment.
Tina Fuchs +11 more
doaj +1 more source
Distribution of immunoglobulin heavy chains in diseased synovia. [PDF]
Journal of Clinical Pathology, 1986 Synovium from 142 patients with 12 different arthropathies was examined for the distribution of alpha, delta, gamma, and mu immunoglobulin heavy chains. A high proportion of plasma cells in the superficial subintima in all diseases reacted for alpha heavy chains. Only in rheumatoid disease did the synovium contain more than 10% of plasma cells reacting
Freemont, AJ, Rutley, C.
openaire +4 more sources
Immunoglobulin Heavy Chain Exclusion in the Shark
PLoS Biology, 2008 The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes. Adaptive responses to immune challenge are based on the expression of a single species of antigen receptor per cell; and in B cells, this is mediated in part by allelic exclusion at the Ig heavy (H) chain ...
Wendy Feng +6 more
openaire +5 more sources
Journal of Cell Biology, 1986 A rat monoclonal antibody specific for immunoglobulin (Ig) heavy chain binding protein (BiP) has allowed the examination of the association of BiP with assembling Ig precursors in mouse B lymphocyte-derived cell lines.
D. Bole, L. Hendershot, J. Kearney
semanticscholar +1 more source
Monoclonal gammopathy of renal significance: Spectrum of diseases and approach to a case
Saudi Journal of Kidney Diseases and Transplantation, 2021 The occurrence of kidney diseases associated with a monoclonal gammopathy in the absence of symptomatic multiple myeloma is increasingly recognized. When the kidney is involved, the monoclonal etiology of these diseases results in clinical and laboratory
Rohit Tewari +5 more
doaj +1 more source
Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species
Frontiers in Immunology, 2022 Studies in humans and mice indicate the critical role of the surrogate light chain in the selection of the productive immunoglobulin repertoire during B cell development.
Marek Sinkora +5 more
doaj +1 more source
Maturation of the Human Immunoglobulin Heavy Chain Repertoire With Age [PDF]
Frontiers in Immunology, 2020 B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied. We extensively investigated age-related alterations of naïve and antigen-experienced immunoglobulin heavy chain (IgH) repertoires.
Marie Ghraichy +18 more
openaire +5 more sources