Results 1 to 10 of about 22,523 (167)

Anticancer Potency of Dimethyl 2-(2-Hydroxy-2-Methoxypropilidine) Malonate in Kombucha

open access: yesJurnal Biodjati, 2022
Kombucha has an anticancer potency because it has dimethyl 2-(2-hydroxy-2-methoxypropilidine) malonate compound. The research aimed to verify the compound dimethyl 2-(2-hydroxy-2-methoxypropilidine) malonate as an anticancer with the in-silico method ...
Opik Taupiqurrohman   +3 more
doaj   +2 more sources

Malonate inhibits virulence gene expression in Vibrio cholerae. [PDF]

open access: yesPLoS ONE, 2013
We previously found that inhibition of the TCA cycle, either through mutations or chemical inhibition, increased toxT transcription in Vibrio cholerae.
Yusuke Minato   +2 more
doaj   +2 more sources

Preparation of mono-substituted malonic acid half oxyesters (SMAHOs)

open access: yesBeilstein Journal of Organic Chemistry, 2021
The use of mono-substituted malonic acid half oxyesters (SMAHOs) has been hampered by the sporadic references describing their preparation. An evaluation of different approaches has been achieved, allowing to define the best strategies to introduce ...
Tania Xavier   +4 more
doaj   +1 more source

Probing the Binding Requirements of Modified Nucleosides with the DNA Nuclease SNM1A

open access: yesMolecules, 2021
SNM1A is a nuclease that is implicated in DNA interstrand crosslink repair and, as such, its inhibition is of interest for overcoming resistance to chemotherapeutic crosslinking agents.
Eva-Maria Dürr, Joanna F. McGouran
doaj   +1 more source

Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites Similar to UCP2

open access: yesBiomolecules, 2023
Uncoupling protein 3 (UCP3) belongs to the mitochondrial carrier protein superfamily SLC25 and is abundant in brown adipose tissue (BAT), the heart, and muscles.
Jürgen Kreiter   +2 more
doaj   +1 more source

Sodium Malonate Inhibits the AcrAB-TolC Multidrug Efflux Pump of Escherichia coli and Increases Antibiotic Efficacy

open access: yesPathogens, 2022
There is an urgent need to find novel treatments for combating multidrug-resistant bacteria. Multidrug efflux pumps that expel antibiotics out of cells are major contributors to this problem.
Allea Cauilan, Cristian Ruiz
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of diethyl 2-[4-(4-fluorophenyl)-2-methyl-4-oxobutan-2-yl]malonate

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2018
The title compound, C18H23FO5, was synthesized by reacting diethyl malonate with 1-(4-fluorophenyl)-3-methylbut-2-en-1-one. The molecule adopts a loose conformation stabilized by weak C—H...O and C—H...π interactions.
Sandeep Chandrashekharappa   +4 more
doaj   +1 more source

Crystal structure of diethyl 2-[(2-sulfanylquinolin-3-yl)methylidene]malonate

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C17H17N O4S, the quinoline ring system is nearly planar, with a maximum deviation of 0.0496 (16) Å. A weak intramolecular C—H...O interaction is observed.
Rihanabanu   +4 more
doaj   +1 more source

Theoretical Evaluation of Refractive Index in Binary Liquid Mixtures

open access: yesE-Journal of Chemistry, 2005
The density and refractive index (RI) for four binary liquid mixtures: diethyl malonate + dimethylformamide (DEM+DMF), diethyl malonate + Hexane (DEM+HEX), diethyl malonate + tetrahydrofuran (DEM+THF), diethyl malonate + 1,4-dioxane (DEM+DO) have been ...
Shipra Baluja   +3 more
doaj   +1 more source

Disodium malonate impairs human sperm motility by inhibiting succinate dehydrogenase activity [PDF]

open access: yesJichu yixue yu linchuang
Objective To investigate the impact of succinate dehydrogenase (SDH) on the modulation of human sperm functions. Methods The isolated human sperm were co-incubated with different concentrations (10, 20, 40 mmol/L) of SDH inhibitor
PENG Zhen, WEN Qin, LU Jing, TU Zeliang, CHENG Yimin
doaj   +1 more source

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