Results 1 to 10 of about 197,127 (261)
The protein encoded by the human proto-oncogene c-myc. [PDF]
Proceedings of the National Academy of Sciences, 1984 The proto-oncogene c-myc may play a role in controlling the growth and division of normal cells, and abnormalities of the gene have been implicated in the genesis of a substantial variety of human tumors. To facilitate further study of these issues, we developed antisera that permit the identification and isolation of the protein encoded by the human ...
Gary Ramsay, J M Bishop, Gerard I. Evan
semanticscholar +4 more sources
Structure of the protein encoded by the chicken proto-oncogene c-myb. [PDF]
Molecular and Cellular Biology, 1986 The retroviral oncogene v-myb arose by transduction of the chicken proto-oncogene c-myb. We isolated and sequenced cDNA that represents the entire coding domain of chicken c-myb. By transcribing the cDNA into mRNA in vitro and then translating the RNA, we were able to document the integrity of the cDNA and to identify the codon responsible for ...
J M Bishop, S Gerondakis
semanticscholar +6 more sources
Subcellular Localization of the Human Proto-oncogene Protein DEK [PDF]
Journal of Biological Chemistry, 2001 Recent data revealed that DEK associates with splicing complexes through interactions mediated by serine/arginine-repeat proteins. However, the DEK protein has also been shown to change the topology of DNA in chromatin in vitro. This could indicate that the DEK protein resides on cellular chromatin.
Claudia Gruss +4 more
openaire +5 more sources
Effects of Proto-oncogene Protein DEK on PCAF Localization [PDF]
Biomolecules and Therapeutics, 2007 The proto-oncogene protein DEK is a nuclear binding phosphoprotein that has been associated with various human diseases including leukemia. Histone acetylation is an important post-translational modification which plays important role in transcriptional regulation.
Seok-Cheol Lee +3 more
openaire +3 more sources
Protein Product of Proto-Oncogene c-mil [PDF]
Molecular and Cellular Biology, 1986 Using antipeptide antibodies with specificity for the carboxyl termini of v-raf and v-mil protein products, two proteins with apparent molecular weights of approximately 71,000/73,000 and 215,000 were detected in immunoprecipitates from normal uninfected chicken cells.
B Schroeer, Klaus Bister, T Patschinsky
openaire +3 more sources
Inhibition of the hTERT promoter by the proto-oncogenic protein TAL1 [PDF]
Leukemia, 2009 Telomerase activity, which has fundamental roles in development and carcinogenesis, strongly depends on the expression of human telomerase reverse transcriptase (hTERT), its catalytic subunit. In this report, we show that the basic helix-loop-helix factor, TAL1 (T-cell acute lymphoblastic leukemia 1), is a negative regulator of the hTERT promoter ...
M. Duc Dodon +7 more
openaire +3 more sources
Transcriptional activation of c-myc proto-oncogene by WT1 protein [PDF]
Oncogene, 2004 The Wilms' tumor 1 gene (WT1) plays an essential role in urogenital development and malignancy. Through DNA binding, WT1 can either enhance or repress transcription depending on the context of the DNA-binding sites or the cell type in which it is expressed.
Jian Liu +3 more
openaire +2 more sources
Structure-specific binding of the proto-oncogene protein DEK to DNA [PDF]
Nucleic Acids Research, 2003 The ubiquitous proto-oncogene protein DEK has been found to be associated with chromatin during the entire cell cycle. It changes the topology of DNA in chromatin and protein-free DNA through the introduction of positive supercoils. The sequence and structure specificities of DEK-DNA interactions are not completely understood. The binding of DEK to DNA
Claudia Gruss +3 more
openaire +3 more sources
Association of the proto‐oncogene product Dbl with G protein βγ subunits [PDF]
FEBS Letters, 1999 The Rho family of GTP‐binding proteins has been implicated in the regulation of various cellular functions including actin cytoskeleton‐dependent morphological change. Its activity is directed by intracellular signals mediated by various types of receptors such as G protein‐coupled receptors.
Kazuhiko Nishida +2 more
openaire +3 more sources
Protein Truncation Is Required for the Activation of the c-myb Proto-Oncogene [PDF]
Molecular and Cellular Biology, 1991 The protein product of the v-myb oncogene of avian myeloblastosis virus, v-Myb, differs from its normal cellular counterpart, c-Myb, by (i) expression under the control of a strong viral long terminal repeat, (ii) truncation of both its amino and carboxyl termini, (iii) replacement of these termini by virally encoded residues, and (iv) substitution of ...
Thomas Graf +2 more
openaire +3 more sources