Results 1 to 10 of about 2,468,898 (371)
Zebrafish VEGF receptors: a guideline to nomenclature. [PDF]
PLoS Genetics, 2008 In placental mammals (eutherians), there exist three paralogous genes of the vascular endothelial growth factor (VEGF) receptor family, namely FLT1 (also named VEGFR1), KDR (also named FLK1 and VEGFR2), and FLT4 (also named VEGFR3).
Jeroen Bussmann +4 more
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The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling. [PDF]
PLoS Computational Biology, 2009 Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific receptors on the endothelial cells lining blood vessels. The signaling cascade triggered eventually leads to the formation of new capillaries, a process called ...
Marianne O Stefanini +3 more
doaj +5 more sources
A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis. [PDF]
Nat Commun, 2017 Non-classical secretory vesicles, collectively referred to as extracellular vesicles (EVs), have been implicated in different aspects of cancer cell survival and metastasis.
Feng Q +8 more
europepmc +2 more sources
Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. [PDF]
Journal of Clinical Investigation, 1995 Endothelial cells constitute an essential integrator of factors that effect blood vessel remodeling induced by chronic hypoxia. We hypothesized that vascular endothelial growth factor (VEGF) may participate in the lung response to acute and to chronic ...
Rubin M. Tuder, B E Flook, N. F. Voelkel
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Inhibition of VEGF receptors causes lung cell apoptosis and emphysema [PDF]
Journal of Clinical Investigation, 2000 Pulmonary emphysema, a significant global health problem, is characterized by a loss of alveolar structures. Because VEGF is a trophic factor required for the survival of endothelial cells and is abundantly expressed in the lung, we hypothesized that ...
Yasunori Kasahara +7 more
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PLoS ONE, 2013 Vascular endothelial growth factor (VEGF) is up-regulated during mesothelial to mesenchymal transition (MMT) and has been associated with peritoneal membrane dysfunction in peritoneal dialysis (PD) patients.
María Luisa Pérez-Lozano +9 more
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The impact of high density receptor clusters on VEGF signaling [PDF]
Electronic Proceedings in Theoretical Computer Science, 2013 Vascular endothelial growth factor (VEGF) signaling is involved in the process of blood vessel development and maintenance. Signaling is initiated by binding of the bivalent VEGF ligand to the membrane-bound receptors (VEGFR), which in turn stimulates ...
Ye Chen +3 more
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VEGF Receptor Signaling in Tumor Angiogenesis [PDF]
The Oncologist, 2000 Abstract The growth of human tumors and development of metastases depend on the de novo formation of blood vessels. The formation of new blood vessels is tightly regulated by specific growth factors that target receptor tyrosine kinases (RTKs).
Gerald McMahon
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Fox(y) regulators of VEGF receptors. [PDF]
Circ Res, 2014 Vascular development is a multistep process that initially involves vasculogenesis, the process of de novo formation of the primitive vasculature from mesodermal precursors, and angiogenesis, that involves sprouting and remodeling of the primitive vasculature.1 This is followed by vascular fate specification steps that define formation of arterial ...
Ricard N, Simons M.
europepmc +5 more sources
The docking protein FRS2α is a critical regulator of VEGF receptors signaling. [PDF]
Proc Natl Acad Sci U S A, 2014 Significance Regulation of vascular endothelial growth factor (VEGF) signaling plays a central role in a range of biological processes from embryonic and perinatal vascular development to maintenance of the mature adult vasculature to regulation of ...
Chen PY +6 more
europepmc +2 more sources