Results 121 to 130 of about 488,887 (308)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

beta(2)-Microglobulin and Phosphate Clearances Using a Wearable Artificial Kidney: A Pilot Study

, 2009
Background: Additional small-solute clearances during standard thrice-weekly hemodialysis treatments have not improved patient survival. However, these treatments have limited middle-molecule clearances.
Ronco C, Davenport A, Gura V, Beizai M, Ezon C   +4 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A facile synthesis of a difluoromethylene analog of beta-aspartyl phosphate as an inhibitor of L-aspartate-beta-semialdehyde dehydrogenase

, 2003
An efficient and high yield procedure for the synthesis of the difluoromethylene analog of beta-aspartyl phosphate, beta-aspartyl difluoromethylenephosphonate (betaAFP), is described.
Viola, R. E., 韩守法, Moore, R. A., Han, S. F.   +3 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Geospatial Assessment of Water Suitability for Rabbitfish (Siganus sp.) Cultivation in Moyohilir Waters, West Nusa Tenggara

Ilmu Kelautan
Rabbitfish (Siganus sp.) is an economically valuable fishery commodity widely consumed in eastern Indonesia, with increasing demand for animal protein. Indonesia’s rabbitfish production rose steadily from 13.6 million tons in 2011 to 22.6 million tons in
Sarjito Sarjito, Beta Ali Syahbana, Muhammad Helmi, Anindya Wira Satriya, Parichat Wetchayont, Restiana Wisnu Ariyati   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Time-resolved metabolomics analysis of beta-cells implicates the pentose phosphate pathway in the control of insulin release

, 2013
Insulin secretion is coupled with changes in beta-cell metabolism. To define this process, 195 putative metabolites, mitochondrial respiration, NADP(+), NADPH and insulin secretion were measured within 15 mm of stimulation of clonal INS-1 832/13 beta ...
Goehring, Isabel, Sharp, Geoffrey W. G., Koeck, Thomas, Nagorny, Cecilia L F, Danielsson, Anders P H, Göhring, Isabel, Sharp, Geoffrey W G, Wollheim, Claes, Straub, Susanne G., Andersson, Lotta E, Straub, Susanne G, Mulder, Hindrik, Sharoyko, Vladimir V, Sharoyko, Vladimir, Nagorny, Cecilia, Köck, Thomas, Malmgren, Siri, Danielsson, Anders, Spégel, Peter, Andersson, Lotta   +19 more
core   +1 more source