Results 151 to 160 of about 1,209,776 (284)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Two novel paralogous <i>C. elegans</i> proteins bind to LON-1 but do not have a major role in body size regulation. [PDF]

MicroPubl Biol
Gardner DM, Williams B, Liu Z, Liu J.
europepmc   +1 more source

ＩＢＳ法和ＩＴＯ法应用于全同胞鉴定中的探讨

Zhongshan Daxue xuebao. Yixue kexue ban, 2014
摘 要： 【目的】 应用ＧｏｌｄｅｎｅｙｅＴＭ ２０Ａ扩增体系，讨论ＩＢＳ法和ＩＴＯ法在全同胞鉴定中的应用价值。【方法】 选取１５０对全同胞和５００对无关个体，用ＧｏｌｄｅｎｅｙｅＴＭ２０Ａ体系进行１９个常染色体ＳＴＲ基因座的扩增，计算状态一致性评分（ＩＢＳ），用ＩＴＯ法分别计算全同胞关系指数（ＦＳＩ）、半同胞关系指数（ＨＳＩ）及其比值（ＦＳＩ：ＨＳＩ）。【结果】 在检测ＧｏｌｄｅｎｅｙｅＴＭ ２０Ａ体系１９个基因座时，（１）当两个体的ＩＢＳ≥２２时，倾向于全同胞；当ＩＢＳ≤１３时，倾向于无关个体 ...
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Behavioral and Morphological Effects of Natural Sweeteners on <i>Caenorhabditis elegans</i>. [PDF]

MicroPubl Biol
Patel D, Shults C, Manjarrez JR.
europepmc   +1 more source

New Zealand White rabbits and Experimental Spinal Surgery: Our "point de vue

, 2009
Stebel M, Canavese B, Cavalli F                                                   , Diméglio A, Lorenzon A, Canavese F   +5 more
core   +1 more source

uPAR在类风湿关节炎成纤维样滑膜细胞中的功能及机制

Zhongshan Daxue xuebao. Yixue kexue ban, 2014
【目的】 采用RNA干扰(RNAi)技术阻断类风湿关节炎(RA)成纤维样滑膜细胞(FLS)尿激酶型纤溶酶原激活物受体(uPAR)基因的表达,探讨uPAR基因沉默后对RA-FLS功能产生的影响及有关机制?【方法】 收集行关节置换术或滑膜清理术的RA患者的滑膜组织,组织块法培养RA-FLS?通过阳离子脂质体转染的方法,转染体外合成的特异性uPAR-siRNA;利用荧光定量PCR法和Western blotting法检测uPAR沉默效果;CCK8法检测细胞增殖抑制率;流式细胞技术检测细胞周期改变 ...
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Effectiveness of a nature-based social prescribing intervention on loneliness and health-related quality of life among vulnerable urban adults (RECETAS-BCN): an observer-blinded randomised controlled trial. [PDF]

Lancet Reg Health Eur
Coll-Planas L, Masó-Aguado M, Briones-Buixassa L, Morató A, Mendez S, Carbó A, Fuente-Vidal A, Olivella-Cirici M, Casajuana Kögel C, Bartova A, Cattaneo L, Jansson AH, Kolster A, Novotna B, Opacin N, Papon V, Puntscher S, Rautiainen LJ, Rochau U, Blancafort-Alias S, Daher C, Bekessy S, Acurio-Páez D, Garcia Velez GE, Holmerova I, Johnson K, Segura LG, Siebert U, Pitkälä KH, Sanz S, Litt JS.   +30 more
europepmc   +1 more source

标准化肾肿瘤影像解剖特征与术式选择的相关性

Zhongshan Daxue xuebao. Yixue kexue ban, 2014
【目的】 评价基于肾肿瘤影像解剖特征的RENAL评分系统临床应用的稳定性,并探讨该评分系统与局限性肾肿瘤患者术式选择的相关性?【方法】 回顾性分析2011年8月至2012年8月共225例在解放军总医院行手术治疗的局限性肾肿瘤患者的术前CT及临床资料,由三名影像科医师采用RENAL评分系统分别进行总分和R(最大径)?E(外生性/内生性)?N(与肾窦的距离)?A(腹/背侧)?L(沿肾纵轴的关系)和h(是否与肾蒂血管接触)各变量评分,采用统计学方法比较三名观察者评分的一致性?依据总评分将患者分为为低?中 ...
doaj