Results 141 to 150 of about 1,064,749 (319)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2012 【目的】 探讨慢性阻塞性肺疾病(COPD) 患者动态肺过度充气与运动能力的关系。【方法】 对26例稳定期中重度COPD患者和12例健康人进行常规肺通气功能、弥散功能、肺容量和症状限制递增功率踏车心肺运动测试,在静息状态和运动过程中每隔1 min记录受试者潮式呼吸时流速容积曲线和深吸气量(IC)。【结果】 COPD 组在症状限制递增功率运动高峰时, IC(L)较静息状态下降(1.55 ± 0.46 vs 2.17 ± 0.50,P < 0.001); 运动高峰时ΔIC与摄氧量呈负相关 (r = -0 ...
doaj
Multiresolution Computed Tomography Viewer
The Multiresolution Computed Tomography Viewer, MCTV, allows large images from a micro-CT to be displayed over the web, whilst being easy to set up and not requiring any plug-ins to be enabled apart from JavaScript which is by default enabled on all ...
Cox, Simon +2 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
ＳＢ２０２１９０对卡英酸诱导的癫痫大鼠模型认知功能的影响及机制
Zhongshan Daxue xuebao. Yixue kexue ban, 2014 摘 要：【目的】 研究ｐ３８丝裂原活化蛋白激酶（ｐ３８ＭＡＰＫ）选择性抑制剂ＳＢ２０２１９０对卡英酸（ＫＡ）致痫大鼠学习、记忆能力的影响及其与海马神经元凋亡的关系的探讨。【方法】４０只大鼠随机分为４组：假处理组、模型组和ＳＢ２０２１９０低、高剂量组（剂量分别为７．５ ｍｇ／ｋｇ，３０ ｍｇ／ｋｇ），对各组大鼠进行行为学观察，应用Ｍｏｒｒｉｓ水迷宫试验，检测大鼠学习和记忆能力，同时通过ＢＬ－４２０Ｆ生物机能实验系统描记脑电图的变化，采用 ＴＵＮＥＬ 检测细胞凋亡并计算凋亡率 ...
doaj
, 2010 Finanskrisen påviste alvorlige mangler i dagens bankregulering. Som en direkte årsak har Baselkomiteen for banktilsyn utgitt et forslag til nytt kapital- og likviditetsregelverk (Basel III), som skal forbedre banksektorens evne til å absorbere sjokk, og dermed redusere smitteeffekten til makroøkonomien.
openaire +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Shareholder gains for bidder firms: an event study on the U.S. petroleum industry
, 2010 The purpose of this paper is to examine the merger gains to the bidder firms’ shareholders in the U.S. petroleum industry, through an event study, and through a cross‐sectional regression on the event study results. This paper utilizes three different event windows of 3, 11 and 21 days, symmetric around the event date in the event study.
openaire +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
An improved sequencing-based strategy to estimate locus-specific DNA methylation [PDF]
, 2015 core +1 more source