Results 141 to 150 of about 10,676,023 (208)

Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in Ewing sarcoma

Molecular Oncology, Volume 19, Issue 4, Page 961-964, April 2025.
Ewing sarcoma is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF complex via ARID1A. ARID1A's ability to form biomolecular condensates is crucial for tumor growth, making it a potential therapeutic target. However, targeting these transient condensates is challenging, requiring further research. Ewing sarcoma,
Erich J. Sohn, David S. Libich
wiley   +1 more source

Plasma Trough Concentrations of Beta-Lactam Antibiotics in the Early Phase of Septic Shock. [PDF]

Acta Anaesthesiol Scand
Hägglund M, Brink M, Martin US, Bremell D, Svensson CJ.   +4 more
europepmc   +1 more source

Effects of (D-Ala2, Met5)-enkephalinamide and naloxone on ACTH and corticosterone secretion.

, 1986
Kozo Hashimoto, Shuso Suemaru, Teruhiko Hattori, Toshihiro Takao, Hiroshi Inoué, MASANORI SUGAWARA, Jingo Kageyama, Zensuke Ota   +7 more
openalex   +2 more sources

Genomic landscape and preclinical models of angiosarcoma

Molecular Oncology, Volume 19, Issue 4, Page 965-983, April 2025.
Angiosarcomas are a rare and aggressive cancer with a poor prognosis for patients. The genomic landscape of angiosarcoma can be highly complex and heterogenous; however, recent studies have identified some common features especially within anatomic and molecular subgroups.
Annaleigh Benton, Bozhi Liu, Lauren E. Gartenhaus, Jason A. Hanna   +3 more
wiley   +1 more source

Sounds of Hidden Agents: The Development of Causal Reasoning About Musical Sounds. [PDF]

Dev Sci
Kim M, Schachner A.
europepmc   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, Volume 19, Issue 5, Page 1386-1403, May 2025.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Putting All Our Eggs in One Basket While Dancing Around the Elephant in the Room: How Health and Economy Conversations Need to Better Align. [PDF]

Health Promot J Austr
Crawford G, Trebeck K.
europepmc   +1 more source

Naloxone Does Not Modify the Hemodynamic and Neuroendocrine Effects of Clonidine in Normal Humans

, 1985
Roberto Pedrinelli, Gianpaolo Bernini, Antonio Salvetti   +2 more
openalex   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

HR-MS Analysis of the Covalent Binding of Edaravone to 5-Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5-Formylcytidine Residue. [PDF]

Rapid Commun Mass Spectrom
Regnault R, Kouach M, Goossens L, Thuru X, Bailly C, Goossens JF.   +5 more
europepmc   +1 more source