Results 141 to 150 of about 278,683,873 (354)

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Naloxone Does Not Antagonize General Anesthesia in the Rat

, 1978
Marilyn H. Harper, P. Winter, Brynte H. Johnson, Edmond I. Eger   +3 more
openalex   +1 more source

Obituary: Arthur Cruickshank 1932 - 2011. A native Gondwanan, who studied the former continent's fossil tetrapods [PDF]

, 2012
Dr Arthur Richard Ivor Cruickshank died on 4th December 2011, aged 79, in the Borders General Hospital, Melrose, Scotland. Arthur Cruickshank was part of the post-war generation of palaeontologists who laid the foundations on which today’s ...
Benton, M J, Fraser, Nicholas C, Noè, L F, Taylor, Michael A   +3 more
core  

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

A double blind trial of naloxone in the treatment of acute stroke. [PDF]

, 1984
Richard Fallis, Monika Fisher, Rogerio A. Løbo   +2 more
openalex   +1 more source

Orthogonal Wavelets via Filter Banks: Theory and Applications [PDF]

, 2000
Wavelets are used in many applications, including image processing, signal analysis and seismology. The critical problem is the representation of a signal using a small number of computable functions, such that it is represented in a concise and ...
Winkler, J.R.
core  

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Potentiation of pentazocine analgesia by low-dose naloxone. [PDF]

, 1988
Jon D. Levine, Newton C. Gordon, Yetunde O. Taiwo, Terence J. Coderre   +3 more
openalex   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Naloxone can alter experimental pain and mood in humans [PDF]

, 1981
Jonathan Schull, Hillard Kaplan, Charles P. O’Brien   +2 more
openalex   +1 more source