Results 21 to 30 of about 1,232 (181)

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Chemical composition of free tropospheric aerosol for PM1 and coarse mode at the high alpine site Jungfraujoch [PDF]

, 2007
The chemical composition of submicron (fine mode) and supermicron (coarse mode) aerosol particles has been investigated at the Jungfraujoch high alpine research station (3580 m a.s.l., Switzerland) as part of the GAW aerosol monitoring program since 1999.
Coe, Hugh, Wiangartner, E., Bower, Keith N., E. Weingartner, Crosier, Jonathan, Cozic, Julie, Weingartner, Ernest, Baltensperger, U., Coe, H.; id_orcid, Steinbacher, Martin, Henne, S., Henning, S., J. Crosier, Bower, K., Flynn, Michael, U. Baltensperger, Baltensperger, Urs, Weingartner, E., Flynn, M., Verheggen, B., Cozic, J., Petzold, A., Bower, K.N., Verheggen, Bart, S. Henning, Bower, K. N.; id_orcid, Crosier, J., Collaud Coen, M., S. Henne, Crosier, J.; id_orcid, Henne, Stephan, Henning, Silvia, A. Petzold, H. Coe, Petzold, Andreas, M. Steinbacher, B. Verheggen, Bower, K. N., M. Flynn, K. N. Bower, J. Cozic, Collaud Coen, Martine, Coe, H., Steinbacher, M., Flynn, M.; id_orcid, M. Collaud Coen   +45 more
core   +1 more source

Frugal Innovation as a Strategic Mechanism Linking Learning, International Growth Orientation, and Performance

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines how international growth orientation and organizational learning capability jointly influence frugal innovation and organizational performance. Survey data were collected from 342 manufacturing firms in Santa Catarina (Southern Brazil) and analyzed using partial least squares structural equation modeling and multigroup ...
Júlia Quintino Sant'Ana, Giancarlo Gomes, Joaquin Alegre, Paula Gulart Munhoz   +3 more
wiley   +1 more source

A 2000 Year Saharan Dust Event Proxy Record from an Ice Core in the European Alps

Dust events originating from the Saharan desert have far reaching environmental impacts but the causal mechanism of magnitude and occurrence of Saharan dust events (SDEs) during the pre-instrumental era requires further research, particularly as a ...
Mayewski, Paul, Clifford, Heather
core   +2 more sources

Recent Strategies Toward Durable and Ion‐Tolerant Transition Metal‐Based Electrocatalysts in Seawater Electrolysis

Carbon Energy, EarlyView.
Recent strategies address these challenges through ion‐specific regulation, encompassing chloride‐tolerant and chloride‐regulating anodes together with cathode designs that suppress OH− accumulation and Mg2+/Ca2+ coupling. This ion‐management‐oriented framework provides general guidelines for achieving stable, selective, and scalable seawater ...
Lina Li, Wenda Zhang, Xinti Yu, Ning Han, Zhangxing Chen, Heng Zhao   +5 more
wiley   +1 more source

Dental development in the tropical gar (Atractosteus tropicus) and the evolution of vertebrate dentitions

Developmental Dynamics, EarlyView.
Abstract Background Dentitions have diversified enormously during vertebrate evolution, involving reductions, modifications, or allocations to prey seizing and processing regions. A combination of ancient and novel features related to dental and oropharyngeal apparatuses is found in extant lineages of non‐teleost fishes, such as the gars.
Anna Pospisilova, Jan Stundl, Lenin Arias‐Rodriguez, Robert Cerny, Vladimír Soukup   +4 more
wiley   +1 more source

Alternative Price Dynamics and Valuation of Flexible Strategies

International Journal of Finance &Economics, EarlyView.
ABSTRACT In this article, we study the optimal operational strategy of production projects. We investigate different underlying price models and determine the optimal barriers of transition to suspension, recovery, or irreversible abandonment of productive activity.
Cristina Bertolosi, Gianluca Fusai, Ioannis Kyriakou   +2 more
wiley   +1 more source

Temporal and Spatial Distribution Pattern of Population at the South End of Hu Line in Recent 25 Years

, 2019
The southern end of Hu Line mainly involves Sichuan and Yunnan provinces. In this paper, the spatial-temporal distribution pattern of population is analyzed by Standard Deviation Ellipse (SDE) and Exploratory Spatial Data Analysis (ESDA).
Huan Yu, Yuting Liang
core   +1 more source

Sewage Sludge and Cashew Bagasse Biochars Promote Changes in Selected Physical Attributes Related to the Structure of Degraded Dryland Soil

Journal of Plant Nutrition and Soil Science, EarlyView.
This study evaluated biochars from co‐pyrolysis of sewage sludge and cashew residues on physical quality of a degraded loamy sand soil. SPB applied at 20 Mg ha−1 reduced bulk density by 7.74%, whereas most porosity attributes were driven by soil reconsolidation rather than biochar. Aggregate stability varied with biochar type, with SPB promoting larger
João Marcos Rodrigues dos Santos, Ícaro Vasconcelos do Nascimento, Gilvanete da Silva Henrique, Tiago da Costa Dantas Moniz, Francisco Luan Almeida Barbosa, Alexandre dos Santos Queiroz, Adriana Guirado Artur, Mirian Cristina Gomes Costa, Helon Hébano de Freitas Sousa, Odair Pastor Ferreira, Laís Gomes Fregolente, Antônio Gomes de Souza Filho, Romildo Lopes de Oliveira Filho, Arthur Prudêncio de Araujo Pereira, Jaedson Cláudio Anunciato Mota   +14 more
wiley   +1 more source

Diarrhoea Among Under-Five Children and Household Water Treatment and Safe Storage Factors in Mkuranga District, Tanzania [PDF]

, 2012
In Mkuranga district diarrhoea was among the top ten causes of morbidity and mortality among children under the age of five. Household water treatment and safe storage also known as point of use water treatment (POU) has been shown to be an effective ...
Kakulu, Remidius Kamuhabwa, Kakulu, R.K.
core