Results 31 to 40 of about 699,930 (194)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Utilidade da PET/CT, (18F-FDG), no estudo do linfoma Hodgkin e linfoma não Hodgkin

Saúde & Tecnologia, 2009
Os linfomas são tumores estabelecidos a nível do sistema linfático. Devido à sua heterogeneidade classificam-se como Linfoma Hodgkin (LH) e Linfoma não Hodgkin (LNH), apresentando diferente prognóstico e seguimento quimioterapêutico.
Marta Milhões, José Rafael Infante, Juan Rayo Madrid, L. B. Garcia, Lina Vieira   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Utilidade do PET/CT na caracterização do nódulo solitário pulmonar

Saúde & Tecnologia, 2011
Introdução – O cancro de pulmão/traqueia e brônquios é a principal causa de morte por neoplasia na União Europeia. A técnica de duas aquisições de imagem em tempos diferentes no Positron Emission Tomography/Computed Tomography (PET/CT) tem sido ...
Ana Graça, Lucia Garcia Bernardo, José Rafael Infante, Juan Rayo Madrid, Lina Vieira   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Factores que influenciam a estabilidade da 18F-FDG

Saúde & Tecnologia, 2011
Introdução – A ausência de um ciclotrão para produção da 2-[18F]Flúor-2-deoxi-D-glucose (18F-FDG) é, actualmente, uma realidade para a maior parte dos centros onde se realizam exames de Tomografia por Emissão de Positrões (TEP),  sendo  importante ...
Ana Graça, Román Sánchez Sánchez, Lucía Garcia Bernardo, Juan Rayo Madrid, Filipa Lucena   +4 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Out-of- hospital mortality in the municipality of Cienfuegos, 2016

Medisur, 2020
Foundation: Mortality data indicate the number of deaths by place, time interval and cause. The evolution of this evidence is the combination of the problems characteristic of the populations living conditions and the conflicts of developing countries ...
Orlando Morera Álvarez, Daylin Madruga Jiménez, Liliana Caridad Romero Castro   +2 more
doaj  

Influence of operator’s professional experience and visual function in the myocardial perfusion scan semiautomatic processing: intra and inter operator variability in quantitative parameters estimation

Saúde & Tecnologia, 2016
Introduction – Myocardial perfusion scan (MPS) has an important role in the diagnosis, evaluation and follow-up of patients with coronary artery disease being the semiautomatic processing widely used for routine clinical practice.
Ana Sofia Reimão, Joana Pereira, Matina Nobre, Fábio Nascimento, Elisabete Carolino, Ilda Poças, Lina Vieira   +6 more
doaj   +1 more source