Results 71 to 80 of about 916,602 (288)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

PET/CT with 18-fluor-fluorodeoxyglucose in the follow-up of the cutaneous malignant melanoma

Saúde & Tecnologia, 2015
Background – Cutaneous malignant melanoma (CMM) is one of the most lethal malignancies and the follow-up involves, in addition to clinical examination and analysis of tumor markers, several imaging methods such as the Positron Emission Tomography ...
Sofia Batanete, J. R. Infante, J. I. Rayo, Lina Vieira   +3 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Centrolene savagei [PDF]

, 2017
Number of Pages: 11Geological SciencesIntegrative ...
Ospina-L., Ana M., Rios-Soto, Julián A., Rivera-Correa, Mauricio, Vargas-Salinas, Fernando   +3 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Micro and nanostructured phases obtained by mechanical alloying - low temperature annealing in AB5-H2 systems [PDF]

, 2015
In this work, the characteristics of a commercial sample of LaNi5 are compared to those of an experimental one obtained by mechanical alloying followed by low temperature annealing.
Esquivel, Marcelo Ricardo Oscar, Obregon, Sergio Alejandro, Zelaya, Maria Eugenia   +2 more
core   +1 more source

Using Largest Lyapunov Exponent to Confirm the Intrinsic Stability of Boiling Water Reactors

Nuclear Engineering and Technology, 2016
The aim of this paper is the study of instability state of boiling water reactors with a method based in largest Lyapunov exponents (LLEs). Detecting the presence of chaos in a dynamical system is an important problem that is solved by measuring the LLE.
Carlos J. Gavilán-Moreno, Gilberto Espinosa-Paredes   +1 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Thermally assisted interlayer magnetic coupling through Ba0.05Sr0.95TiO3 barriers [PDF]

, 2016
We report on the interlayer exchange coupling across insulating barriers observed on Ni80Fe20/Ba0.05Sr0.95TiO3/La0.66Sr0.33MnO3 (Py/BST0.05/LSMO) trilayers.
Alejandro, Gabriela, Aviles Felix, Luis Steven, Carreira, Santiago José, Sirena, Martin, Steren, Laura Beatriz   +4 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source