Results 81 to 90 of about 916,602 (288)

18F-FDG PET/CT IN ANTISYNTHETASE SYNDROME: CASE REPORT

Hematology, Transfusion and Cell Therapy
Introduction/Justification: Antisynthetase syndrome is an autoimmune pathology characterized by production of autoantibodies against aminoacyl tRNA synthetase, mainly anti-Jo-1. Report: Male patient presenting a clinical picture of polyarthritis in hands
Felipe Piccarone Gonçalves Ribeiro, Dihego Ferreira dos Santos, Bárbara Juarez Amorim, Allan de Oliveira Santos, Elba Cristina Sá de Camargo Etchebehere, Ludmila Santiago Almeida, Celso Darío Ramos, Mariana da Cunha Lopes de Lima   +7 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Relation between width of zero-bias anomaly and Kondo temperature in transport measurements through correlated quantum dots: Effect of asymmetric coupling to the leads [PDF]

, 2018
The zero-bias anomaly at low temperatures, originated by the Kondo effect when an electric current flows through a system formed by a spin-1/2 quantum dot and two metallic contacts is theoretically investigated.
Aligia, Armando Ángel, Perez Daroca, Diego Raul, Roura Bas, Pablo Gines   +2 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Distributional extensions of Carollia castanea and Micronycteris minuta from Guatemala, Central America [PDF]

, 2017
Field expeditions in 2011 that inventoried the terrestrial vertebrate fauna of two wildlife protected areas in the tropical Caribbean of Guatemala have produced the first confirmed records of two bats for the country: the white-bellied big-eared bat ...
Barahona, R, López, JE, Nicolle, JA, Ordóñez-Sayle, EJ, Patton, JL, Pérez-Consuegra, SG, Vázquez-Domínguez, E   +6 more
core   +1 more source

Simulation of the Lower Head Boiling Water Reactor Vessel in a Severe Accident

Science and Technology of Nuclear Installations, 2012
The objective of this paper is the simulation and analysis of the BoilingWater Reactor (BWR) lower head during a severe accident. The COUPLE computer code was used in this work to model the heatup of the reactor core material that slumps in the lower ...
Alejandro Nuñez-Carrera, Raúl Camargo-Camargo, Gilberto Espinosa-Paredes, Adrián López-García   +3 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

External Dose to Recovery Teams Following a Wide-area Nuclear or Radiological Release Event. [PDF]

Health Phys, 2021
Kaminski MD, Sanders K, Hepler K, Magnuson M, Slagley J.   +4 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Releasing systems for aerospace industry based upon shape memory alloys: Characterization of materials for actuators [PDF]

, 2018
Releasing and deployment maneuvers carried out during space satellites launching are usually performed by utilizing pyrotechnics loads. However, it is considered convenient to replace this technique by others not requiring explosives (Non Explosive ...
Glücksberg, Andrés, Soul, Hugo Ramon, Yawny, Alejandro Andres   +2 more
core   +4 more sources