Results 51 to 60 of about 401,775 (204)

La communication éditoriale : un outil de légitimation. Le cas de L’Association

open access: yesComicalités, 2013
Dealing with the legitimacy of comic books, researchers mainly focus on external consecration bodies (institutions, medias). Studying the deeds and claims of the producers reveals their direct involvement in this process.
Benjamin Caraco
doaj  

La collection « Mon Histoire » : quand « l’effet collection » favorise l’individu au détriment de l’Histoire

open access: yesRepères, 2013
The book collection “Mon Histoire” by Gallimard editions offers a choice of more than thirty titles. They are diaries written by young girls from different historical and geographical backgrounds.
Anne Vignard
doaj   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

open access: yesAdvanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia   +6 more
wiley   +1 more source

Libros y lecturas en la España de Carlos II

open access: yesE-Spania, 2018
Dans un pays où le roi avait appris à lire et à écrire fort tard, l’accès à la lecture et aux libres ne fut pas chose aisée pour la grande majorité de la population. L’analphabétisme généralisé et l’état désastreux de l’éducation n’ont pas été l’objet de
Ofelia Rey Castelao
doaj   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

open access: yesAdvanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang   +12 more
wiley   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto   +20 more
wiley   +1 more source

La petite maison dans les abattis ou l’art de rédiger aux bois par Jean Antoine de Brûletout, chevalier de Préfontaine dans son habitation de la France équinoxiale (1754-1763)

open access: yesIn Situ, 2013
Among the rare publications devoted to colonial housing in the West Indies and French Guyana, the manual titled “The Rustic House” (Maison rustique à l’usage des habitants de la partie de la France équinoxiale connue sous le nom de Cayenne) published in ...
Emilie d’Orgeix, Céline Frémaux
doaj   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

open access: yesAdvanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu   +12 more
wiley   +1 more source

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