Results 121 to 130 of about 3,429,334 (300)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Éditorial : Un espace dialogique au cœur du développement scientifique du chercheur
Canadian Journal for New Scholars in Education, 2014 Cet article répond, sur une base dialogique, à un étudiant de doctorat en éducation qui, dans le contexte d’un congrès international en éducation, m’a partagé son point de vue critique au regard de la Revue canadienne des jeunes chercheures et chercheurs
Dany Boulanger
doaj
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
مجلة عطاء للدراسات والأبحاثLa réforme du système d’éducation de formation et de recherche scientifique se veut une nécessité sine qua non pour remédier au niveau des apprentissages de base et ce en adoptant un arsenal de mesures effectives.
ربيع فرام
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Une enquête international : représentations sociales, conceptions individuelles et pratiques d’enseignants de quinze pays [PDF]
, 2013 Le travail que nous présentons ici s’insère dans le cadre du projet européen « Biohead-Citizen : Biology, health and Environmental education for better Citizenship » (FP6, CT2-CT2004-506015, Carvalho et al., 2004).
Berger, Dominique +3 more
core
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
A educação repensada no contexto de pandemia da Covid-19
Revista de Educação PUC-CampinasEste texto objetiva analisar como a Organização para a Cooperação e Desenvolvimento Econômico traz a insígnia da educação por meio do discurso da escolaridade interrompida em contexto de pandemia da COVID-19 e quais são as implicações na formação do ...
Andréia Aparecida Simão
doaj +1 more source