Results 101 to 110 of about 60,726,704 (248)
, 2016 International audienceL’impact des technologies numériques sur les apprentissages est une question récurrente qui ne concerne pas le seul champ de la géographie enseignée, mais mérite d’être élargie aux méthodes et aux résultats de la recherche en ...
Genevois, Sylvain
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مجلة عطاء للدراسات والأبحاثLa réforme du système d’éducation de formation et de recherche scientifique se veut une nécessité sine qua non pour remédier au niveau des apprentissages de base et ce en adoptant un arsenal de mesures effectives.
ربيع فرام
doaj
Éditorial : Un espace dialogique au cœur du développement scientifique du chercheur
Canadian Journal for New Scholars in Education, 2014 Cet article répond, sur une base dialogique, à un étudiant de doctorat en éducation qui, dans le contexte d’un congrès international en éducation, m’a partagé son point de vue critique au regard de la Revue canadienne des jeunes chercheures et chercheurs
Dany Boulanger
doaj
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
A educação repensada no contexto de pandemia da Covid-19
Revista de Educação PUC-CampinasEste texto objetiva analisar como a Organização para a Cooperação e Desenvolvimento Econômico traz a insígnia da educação por meio do discurso da escolaridade interrompida em contexto de pandemia da COVID-19 e quais são as implicações na formação do ...
Andréia Aparecida Simão
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Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
L’éducation de base au Cambodge : un système en reconstruction
Revue Internationale d’Éducation de Sèvres, 2002 Erick Garnier, Gérard Renou
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Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source