Results 91 to 100 of about 60,726,704 (248)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Tarefas da educação lingüística no Brasil
Revista Brasileira de Linguística Aplicada, 2005 Com base no conceito de "educação lingüística", os autores discutem a necessidade de atender às demandas sociais por essa educação lingüística e definem as áreas de reflexão e atuação mais importantes para a implementação de uma política de educação ...
Marcos Bagno, Egon de Oliveira Rangel
doaj
Psicologia & Sociedade, 2011 O presente estudo investiga a filiação de uma parcela significativa dos discursos que advogam pela "Educação Inclusiva" às tendências retóricas dos discursos contemporâneos que, antes de constituírem uma efetiva forma de resistência diante dos ...
Pablo Severiano Benevides
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Producción y visibilidad de las revistas en educación sobre la web 2.0 en educación secundaria
RED. Revista de Educación a Distancia, 2014 El presente trabajo es un análisis bibliométrico para identificar la producción y visibilidad de las investigaciones sobre la web 2.0 en educación secundaria, a partir de la base de datos ERIC e ISOC.
Cristina Torres Pascual
doaj +2 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Printemps de la Recherche en Éducation 2021
, 2021 Ne manquez pas les 3 prochaines conférences du Printemps de la Recherche en Éducation 2021 ! Demain, 14h-15h : Philosopher avec les enfants : pourquoi et comment ?
SFERE A Scher
core
Colloque « Environnements, cultures et développements - Éducation à l'environnement et territoire » [PDF]
, 2003 Les 7 et 8 novembre s'est tenu à Niort un colloque organisé par l'Institut de formation et de recherche en éducation à l'environnement (Ifrée) et réunissant chercheurs et praticiens de l'éducation à l'environnement.
Bidou, Jean-Étienne +1 more
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source