Results 11 to 20 of about 7,942 (219)

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Une éducation scientifique émancipatrice pour les élèves de maternelle et leur professeur

Recherches en Éducation, 2018
In this paper, we propose to examine how scientific education can be emancipating for the pupils and the teacher. The actor’s ability of thinking by themselves is put ahead to consider in the same time emancipation of pupils and teacher.
Joël Bisault
doaj   +1 more source

Du côté de la Cité des sciences et de l'industrie

Revue Internationale d’Éducation de Sèvres, 1998
L'utilisation des nouvelles technologies dans l'éducation est une priorité de l'action éducative de la Cité des sciences et de l'industrie. Expos-formation, conférences et visio-conférences, ateliers complètent la panoplie des classes Villette et des ...
Jean-Marie Sani
doaj   +1 more source

Sciences, technologie, société

Revue Internationale d’Éducation de Sèvres, 1997
Le cours de chimie, Chemistry in the Community, n’est pas destiné à des spécialistes de cette discipline mais doit permettre à un plus grand nombre d’élèves de saisir les liens entre sciences, technologie et société.
Edward D. Britton
doaj   +1 more source

Entretien avec le professeur Lakhdar KHARCHI de l’université de M’sila

Langues & Cultures, 2020
A travers cet entretien, la revue Langues & Cultures présente à ses lecteurs et à l’ensemble de la communauté scientifique et universitaire l’intellectuel algérien Pr. Lakhdar KHARCHI.
KHELLADI Sid Ahmed
doaj   +1 more source

Missions de l’éducation scientifique et technique

Revue Internationale d’Éducation de Sèvres, 2000
Science and technology have become the driving forces in social and economic change in modern society. The teaching of these subjects for all is thus a key prerequisite for citizenship insofar as it contemplates individuals’ relationship with knowledge ...
Jean-Louis Martinand
doaj   +1 more source

Propositions pour l’enseignement et la diffusion de la science

Revue Internationale d’Éducation de Sèvres, 2000
Jean Audouze’s proposals for the teaching of sciences cover three areas. As regards new contents, he calls for the introduction of a multi-disciplinary approach alongside the teaching of the fundamental paradigms proper to each discipline and the ...
Jean Audouze
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source