Results 211 to 220 of about 343,358 (250)

Programme-level redesign and student outcomes in specialist post-registration ophthalmic nursing education: a cohort study. [PDF]

BMC Med Educ
Martins Esteves I.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Designing a context-specific intervention in practice: learning from a school-based physical activity intervention. [PDF]

NIHR Open Res
House D, Howard A, Kent-Saisch S, Porter A, Reid T, Morbey R, Emm-Collison L, de Vocht F, Salway R, Jago R.   +9 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Design and Validation of a Clinical Teaching Performance Checklist in Anesthesia Education: A Kane-Based Approach. [PDF]

Adv Med Educ Pract
Sajadi AS, Hamidi N, SedighMaroufi S, Charmchi R, Babajani A, Beiranvand ZP, Moradimajd P.   +6 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Perceived User Experience, Comfort, and Ergonomics of an Add-on Backstop for Hyaluronic Acid Filler Injections: A Simulated-Use Study in Aesthetic Healthcare Professionals. [PDF]

Clin Cosmet Investig Dermatol
Combedazou A, Brunet-Manquat L, Giri JR, Girgis H, Ramus C, Handiwala L.   +5 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Rethinking AI in clinical decision support: a framework for reciprocal human-AI interaction. [PDF]

Front Digit Health
Greengrass CJ.
europepmc   +1 more source