Results 221 to 230 of about 6,171,882 (246)

A transpupillary approach for crosslinking Guinea pig sclera using WST11 and near-infrared light. [PDF]

Sci Rep
Vogels DHJ, Abdulla Y, Myles W, Cummings S, Agemy L, Yechezkel T, Marcovich AL, Scherz A, LaPointe VLS, McFadden SA, Dickman MM.   +10 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Polyphasic characterization of Nocardioides aquaegermanicae sp. nov., a novel water-derived actinobacterium. [PDF]

PLoS One
Zhou S, Kirstein S, Keunecke L, Lehmann A, Schulz LO, Jando M, Pötter G, Neumann-Schaal M, Mast Y, Nouioui I.   +9 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Progressive Changes in Brain Morphology in People With Idiopathic Generalized Epilepsy. [PDF]

Neurology
Xiao F, Zhang Y, Wandschneider B, Binding LP, Giampiccolo D, Fleury M, Delazer L, Pimentel BC, Puntambekar I, Fukuma K, Caciagli L, Sander JW, Duncan JS, Zhou D, Koepp MJ.   +14 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Search for resonances decaying to an anomalous jet and a Higgs boson in proton-proton collisions at s = 13 Te V. [PDF]

Eur Phys J C Part Fields
CMS Collaboration.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Telemedicine use in medical facilities for rural medical care and local governments in Japan. [PDF]

J Rural Med
Matsubara D, Teraura H, Honda Y, Iguchi S, Maeda T, Kotani K.   +5 more
europepmc   +1 more source