Results 31 to 40 of about 1,312,678 (192)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Agronomía Colombiana, 1988 Se revisa en este trabajo la domesticación de plantas por parte de las comunidades indígenas Andoque, Puinave y Ticunas; incluidos dentro de los más conocidos de los numerosos grupos etno-lingüísticos de la Amazonía Colombiana. Las selecciones realizadas
Arguello Arias Heliodoro
doaj
Daniel Senise: pintura como abrigo da imagem
Poiésis, 2018 Daniel Senise é um dos mais emblemáticos pintores da chamada “Geração 80” no Brasil. A partir da obra de Senise, este ensaio procura entender a arte egressa dos 1980 não apenas como a “volta da pintura” — o retorno conservador a um tipo de linguagem ou ...
Daniela Name
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Revista Colombiana de Biotecnología, 2013 Título en ingles: Differential molecular diagnosis Colletotrichum gloeosporioides and Fusarium oxysporum in yam (Dioscorea sp.).Título corto: Diagnóstico molecular en ñameResumen: Las enfermedades de origen fúngico son responsables de las mayores ...
Yeimy Alexandra Pinzón Gutiérrez +2 more
doaj +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Archivos Latinoamericanos de Nutrición, 2004 RESUMEN Las raíces y tubérculos tropicales (RTT) son alimentos básicos de la dieta de los pobladores de estas zonas; son producidos por pequeños y medianos agricultores y se les ha prestado poca atención.
Adriana Blanco-Metzler +2 more
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source