Results 141 to 150 of about 4,415,479 (237)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Programa d’educació sanitària sobre el bon ús dels medicaments [cartell]

Educació sanitària; Bon ús dels medicaments; XerradesEducación sanitaria; Buen uso de los medicamentos; CharlasHealth education; Good use of medicines; TalksEste cartel anuncia un ciclo de charlas informativas sobre medicamentos y hábitos de salud para ...

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Vitalitat i ús del valencià a l'Ajuntament de Sagunt: Resultats de l'aplicació del programa informàtic Indexplà

, 2003
L¿article recull el diagnòstic sobre l¿ús del valencià així com les conclusions a què vam arribar després de l¿aplicació de programa informàtic Indexplà en una entitat local, l¿Ajuntament de Sagunt, municipi del País Valencià que pertany a la comarca del
Pérez Castilla, M. Lluïsa
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Comprehensive reconstruction of the musculoskeletal anatomy in the shoulder using a hybrid 3D ultrasound mosaicking workflow: A pilot study. [PDF]

PLoS One
Sewify A, Steffens M, Perrier N, Antico M, Lavaill M, Edwards C, Pivonka P, Fontanarosa D.   +7 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Recursos de la revista http

Hachetetepé, 2018
Jes´ús Fernández
doaj   +1 more source

Incremental diagnostic value of 24-hour Holter monitoring during training in elite athlete preparticipation screening. [PDF]

BMJ Open Sport Exerc Med
Pi-Rusiñol R, Calvo M, Grazioli G, Adame M, Bolaños Gómez CE, Brugada J, Sitges M, Rodas G, Sanz de la Garza M.   +8 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Projecte Constructiu de Restitució de les quatre columnes de Montjuïc fent ús de materials compostos

El present projecte Constructiu de Restitució de les Quatre Columnes de Montjuïc fent ús de Materials Compostos, pretén reproduir les columnes originals de pedra natural projectades per l’arquitecte Puig i Cadafach (1867-1956), però aplicant les noves ...
Tan Bachs, Isaac
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