Results 121 to 130 of about 4,415,479 (237)
, 2012 CRITERIS DE COMPENSACIÓ URBANISTICA: EL CAS D’UNA FINCA D’ÚS RESIDENCIAL A ÚS D’EQUIPAMENT PÚBLIC .
Garcia-Almirall, M. Pilar +1 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
El Patrimoni arqueològic i el seu ús integrat
Descripció de l’estat dels jaciments arqueològics de l’alta Garrotxa, i proposta d’establiment d’un Parc cultural de la regió, “com un espai on la conservació, l’estudi i l"ús integrat del patrimoni cultural es converteixin en unes eines eficaces per al ...
Alcalde, Gabriel, Sañá Seguí, María
core
Vitalitat i ús del lèxic del parlar de Flix. Variació lingüística generacional
, 2012 Dins el treball de camp desenvolupat per l'autora sobre el parlar de Flix, aquest article se centra en l'estudi del seu lèxic quant a vitalitat i ús, no npmés des d'una perspectiva diatòpica, sinó també ...
Bagés Fortacín, Noemí
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Plataforma de comunicacions sense fil per a ús industrial
, 2014 Tal com el títol del projecte indica, “plataforma de comunicació sense fil per a ús industrial”, en aquest projecte s’ha treballat amb els dispositius de Texas Instruments CC2430/31 que es comuniquen per radiofreqüència implementant la tecnologia ...
Font Comes, Tomàs
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source