Results 61 to 70 of about 1,298,122 (296)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Svět mezi řádky : prolegomena k výzkumu Čapkovy cestopisné tvorby

Bohemica Litteraria, 2013
The study analyzes several aspects of Čapek's travelogues: presentation of the space that is constructed as a system of archetypal universals (e.g. the mountain, the house, the sea, the city) and time that complements the first category.
Agnieszka Janiec-Nyitrai
doaj  

THE END OF ART AND PATOČKA’S PHILOSOPHY OF ART [PDF]

, 2016
In this essay I consider the end-of-art thesis in its metaphysical and empirical versions. I show that both use the correspondence theory of truth as the basis for their conception of the history of art.
Jan, Josl
core  

CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy

Computational and Structural Biotechnology Journal, 2020
Genome editing is the modification of genomic DNA at a specific target site in a wide variety of cell types and organisms, including insertion, deletion and replacement of DNA, resulting in inactivation of target genes, acquisition of novel genetic ...
Yuanyuan Xu, Zhanjun Li
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

KOOPERATIVNO UČENJE U NASTAVI FIZIČKOG VASPITANJA

Naša Škola
U obrazovanju se konstantno preispituju modeli učenja i/ili osmišljavaju novi koji bi učenike pripremili za život u društvu u danas veoma promenjivom okruženju. Istovremeno se socijalnom i emocionalnom učenju (eng.
Svetlana Buišić, Dragan Cvejić
doaj   +1 more source

African therapy for a fractured world(view): The life of founder bishop Johannes Richmond and the invention of tradition and group cohesion in an African Initiated Church

HTS Teologiese Studies/Theological Studies, 2015
In the book The invention of tradition historian Eric Hobsbawm claims that the process of the invention of tradition serves the formation of group cohesion. The different versions of the life story of the founder bishop of the Corinthian Church of South
Cas Wepener
doaj   +1 more source

Reorganizacije slovenske policije [PDF]

, 2012
Namen prispevka je analizirati rezultate projekta javne varnosti, ki je prinesel spremembe v policijski organiziranosti na lokalnem, regionalnem in državnem nivoju in narediti primerjavo z reorganizacijo policijske organizacije, ki poteka ta ...
Anželj, Darko
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Kultura kao afirmacija i negacija, Ne-kultura, Ne-kulturi [PDF]

, 2010
Pojam „kultura“ etimološki znači njegovanje, uzgajanje, obrađivanje. Uz kulturu se vežu vrijednosti i u osnovi zvuči uzvišeno. Stoga Ne-kulturu prije svega poimamo vrijednosno negativno, kao njenu negaciju, rušenje, agresiju.
Kodrnja, Jasenka
core