Results 11 to 20 of about 81,581 (293)

The Potential Role of Rosmarinic Acid and Sinensetin as α-Amylase Inhibitor: In Silico Study [PDF]

Journal of Pure and Applied Chemistry Research, 2019
The study of natural compound as α-amylase inhibitor has been a concern since the synthetic drugs for the management of type 2 diabetes mellitus have several side effects.
Hazna Noor Meidinna, Fatchiyah Fatchiyah   +1 more
doaj   +1 more source

How many α-amylase GH families are there in the CAZy database?

Amylase, 2022
The CAZy database is a web-server for sequence-based classification of carbohydrate-active enzymes that has become the worldwide and indispensable tool for scientists engaged in this research field.
Š. Janeček, B. Svensson
semanticscholar   +1 more source

Accuracy of alpha amylase in diagnosing microaspiration in intubated critically-ill patients. [PDF]

PLoS ONE, 2014
Amylase concentration in respiratory secretions was reported to be a potentially useful marker for aspiration and pneumonia. The aim of this study was to determine accuracy of α-amylase in diagnosing microaspiration in critically ill patients ...
Florent Dewavrin, Farid Zerimech, Alexandre Boyer, Patrice Maboudou, Malika Balduyck, Alain Duhamel, Saad Nseir   +6 more
doaj   +1 more source

New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with in silico studies

Frontiers in Chemistry, 2022
The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs showed a diverse range of activities having IC50 values between 0.80 ± 0.
Yousaf Khan, Shahid Iqbal, Mazloom Shah, Aneela Maalik, R. Hussain, Shoaib Khan, Imran H. Khan, R. Pashameah, Eman Alzahrani, Abd‐ElAziem Farouk, M. Alahmdi, H. S. Abd-Rabboh   +11 more
semanticscholar   +1 more source

Design, Synthesis, In Silico Testing, and In Vitro Evaluation of Thiazolidinone-Based Benzothiazole Derivatives as Inhibitors of α-Amylase and α-Glucosidase

Pharmaceuticals, 2022
In this study, a stepwise reaction afforded thiazolidinone-based benzothiazole derivatives 1–15, and the synthesized derivatives were then screened for biological significance and found to be the leading candidates against α-amylase and α-glucosidase ...
Shoaib Khan, Shahid Iqbal, Marwa Khan, W. Rehman, Mazloom Shah, R. Hussain, Liaqat Rasheed, Yousaf Khan, A. Dera, R. Pashameah, Eman Alzahrani, Abd‐ElAziem Farouk   +11 more
semanticscholar   +1 more source

In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes

Biomolecules, 2021
Type-II diabetes mellitus (T2DM) results from a combination of genetic and lifestyle factors, and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α-amylase enzymes inhibitors can suppress peaks of postprandial glucose ...
Jirawat Riyaphan, Dinh-Chuong Pham, Max K. Leong, C. Weng   +3 more
semanticscholar   +1 more source

Encouragement of Enzyme Reaction Utilizing Heat Generation from Ferromagnetic Particles Subjected to an AC Magnetic Field. [PDF]

PLoS ONE, 2015
We propose a method of activating an enzyme utilizing heat generation from ferromagnetic particles under an ac magnetic field. We immobilize α-amylase on the surface of ferromagnetic particles and analyze its activity.
Masashi Suzuki, Atsushi Aki, Toru Mizuki, Toru Maekawa, Ron Usami, Hisao Morimoto   +5 more
doaj   +1 more source

Synthesis of Novel Benzimidazole-Based Thiazole Derivatives as Multipotent Inhibitors of α-Amylase and α-Glucosidase: In Vitro Evaluation along with Molecular Docking Study

Molecules, 2022
In this study, hybrid analogs of benzimidazole containing a thiazole moiety (1–17) were afforded and then tested for their ability to inhibit α-amylase and α-glucosidase when compared to acarbose as a standard drug.
R. Hussain, S. Iqbal, Mazloom Shah, W. Rehman, Shoaib Khan, Liaqat Rasheed, F. Rahim, A. Dera, Sana Kehili, E. Elkaeed, N. Awwad, Majed A. Bajaber, M. Alahmdi, Hamad Alrbyawi, H. Alsaab   +14 more
semanticscholar   +1 more source

Discovery of Novel Coumarin Derivatives as Potential Dual Inhibitors against α-Glucosidase and α-Amylase for the Management of Post-Prandial Hyperglycemia via Molecular Modelling Approaches

Molecules, 2022
Coumarin derivatives are proven for their therapeutic uses in several human diseases and disorders such as inflammation, neurodegenerative disorders, cancer, fertility, and microbial infections.
Shashank M. Patil, R. M. Martiz, A. Satish, Abdullah M Shbeer, Mohammed Ageel, M. Al‐Ghorbani, Lakshmi V. Ranganatha, Saravanan Parameswaran, R. Ramu   +8 more
semanticscholar   +1 more source

Inhibitors of α‐amylase and α‐glucosidase: Potential linkage for whole cereal foods on prevention of hyperglycemia

Food Science & Nutrition, 2020
The strategy of reducing carbohydrate digestibility by controlling the activity of two hydrolyzing enzymes (α‐amylase and α‐glucosidase) to control postprandial hyperglycemia is considered as a viable prophylactic treatment of type 2 diabetes mellitus ...
Lingxiao Gong, D. Feng, Tianxi Wang, Yuqing Ren, Yingli Liu, Jing Wang   +5 more
semanticscholar   +1 more source