Leukemia Inhibitory Factor Represses GnRH Gene Expression via cFOS during Inflammation in Male Mice. [PDF]
, 2019 BackgroundThe mechanisms whereby neuroinflammation negatively affects neuronal function in the hypothalamus are not clear. Our previous study determined that obesity-mediated chronic inflammation elicits sex-specific impairment in reproductive function ...
Coss, Djurdjica, Lainez, Nancy M
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Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, EarlyView.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Difficulties in the diagnosis of Fabry disease in real clinical practice
Acta Biomedica ScientificaBackground. Fabry disease is a genetically determined disease in which deficiency or complete absence of α-galactosidase A (GLA/AGAL) activity is formed.
A. A. Petrukhina +5 more
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Fabry disease: twenty novel α-galactosidase A mutations causing the classical phenotype [PDF]
, 2001 Grace A. Ashley +4 more
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Role of the PAS2 domain of the NifL regulatory protein in redox signal transduction [PDF]
, 2010 EThOS - Electronic Theses Online ServiceGBUnited ...
Slavny, Peter
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Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design
Advanced Science, EarlyView.Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao +4 more
wiley +1 more source
Synthesis of lipophilic 1-deoxygalactonojirimycin derivatives as D-galactosidase inhibitors
Beilstein Journal of Organic Chemistry, 2010 N-Alkylation at the ring nitrogen of the D-galactosidase inhibitor 1-deoxygalactonojirimycin with a functionalised C6 alkyl chain followed by modification with different aromatic substituents provided lipophilic 1-deoxygalactonojirimycin derivatives ...
Georg Schitter +13 more
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Improved methods for the detection of β-galactosidase activity in colonies ofEscherichia coliusing a new chromogenic substrate: VBzTM-gal (2-(2-(4-(β-d-galactopyranosyloxy)-3-methoxyphenyl)-vinyl)-3-methylbenzothiazolium toluene-4-sulphonate) [PDF]
FEMS Microbiology Letters, 1991 B.W. Bainbridge +5 more
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Biomaterial design strategies for enhancing mitochondrial transplantation therapy
BMEMat, EarlyView.Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang +12 more
wiley +1 more source
Signatures of Altered Gene Expression in Dorsal Root Ganglia of a Fabry Disease Mouse Model
Frontiers in Molecular Neuroscience, 2018 Fabry disease is an X-linked lysosomal storage disorder with involvement of the nervous system. Accumulation of glycosphingolipids within peripheral nerves and/or dorsal root ganglia results in pain due to small-fiber neuropathy, which affects the ...
Kai K. Kummer +3 more
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