Re: development of a next-generation tissue valve using a glutaraldehyde-fixed porcine aortic valve treated with decellularization, α-galactosidase, space filler, organic solvent and detoxification [PDF]
, 2015 Comment on: Development of a next-generation tissue valve using a glutaraldehyde-fixed porcine aortic valve treated with decellularization, α-galactosidase, space filler, organic solvent and detoxification.
P. Poggio +3 more
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Evaluating the Metabolic Basis of α-Gal A mRNA Therapy for Fabry Disease
BiologymRNA injection-based protein supplementation has emerged as a feasible treatment for Fabry disease. However, whether the introduction of LNP-encapsulated mRNA results in the alteration of metabolomics in an in vivo system remains largely unknown.
Zhendong Zhang +6 more
doaj +1 more source
Newborn Screening for Lysosomal Storage Disorders in Belgium
Journal of Inborn Errors of Metabolism and Screening, 2017 Lysosomal storage disorders (LSDs) are a group of metabolic disorders with various clinical presentations, which complicate diagnosis. A pilot study was performed to test the appropriateness and effectiveness of the newborn screening method for Pompe ...
Francois Eyskens MD, PhD +1 more
doaj +1 more source
Rapid Immunochromatographic Detection of Serum Anti-α-Galactosidase A Antibodies in Fabry Patients after Enzyme Replacement Therapy. [PDF]
PLoS ONE, 2015 We developed an immunochromatography-based assay for detecting antibodies against recombinant α-galactosidase A proteins in serum. The evaluation of 29 serum samples from Fabry patients, who had received enzyme replacement therapy with agalsidase alpha ...
Sachie Nakano +12 more
doaj +1 more source
Advanced Science, EarlyView.Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv +13 more
wiley +1 more source
Methyl 2-O-α-D-galactopyranosyl-α-D-mannopyranoside coffee bean α-galactosidase sensitivity of a synthetic fragment of a Trypanosoma brucei GPI anchor [PDF]
, 1998 The synthesis of methyl 2-O-α-D-galactopyranosyl-α-D-mannopyranoside, a fragment of a Trypanosoma brucei Variant Surface Glycoprotein GPI anchor structure, and its susceptibility to hydrolysis by coffee bean α-galactosidase are ...
Brown, J.R. +7 more
core +2 more sources
alpha-galactosidase activity in human saliva [PDF]
, 2008 Objective The purpose of this study was to investigate whether α-galactosidase activity is present in whole and glandular saliva and whether α-galactosidase activity depends on blood type and secretor status.
Kho, Hong-Seop +3 more
core +1 more source
Food Technology and Biotechnology, 2008 α-Galactosidase production by a novel actinomycete strain Streptomyces griseoloalbus in shake flask culture was optimized using response surface methodology.
Grace Sathyanesan Anisha +2 more
doaj
Advanced Science, EarlyView.Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru +6 more
wiley +1 more source
GH36 α-galactosidase from Lactobacillus plantarum WCFS1 synthesize Gal-α-1,6 linked prebiotic α-galactooligosaccharide by transglycosylation. [PDF]
, 2020 α-Galactosidases are potent industrial glycoside hydrolases which are relatively less explored for their transglycosylation potential, especially from Lactobacillus genera.
Shubhashini, A. +4 more
core +1 more source