Results 71 to 80 of about 1,798,291 (314)

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Bioaffinity ultrafiltration coupled with HPLC-ESI-MS/MS for screening potential α-glucosidase inhibitors from pomegranate peel

Frontiers in Nutrition, 2022
Pomegranate peel (PoP) contains plenty of bioactive compounds and exhibits strong activity to prevent postprandial hyperglycaemia and improve diabetes mellitus.
Rujie Shi, Nong Zhou, Han Zhang, Min Gong, Lin Han, Lin Han   +5 more
doaj   +1 more source

High Tree Species Diversity Promotes Thermal Enhancement Response of Microbial Carbon Use Efficiency

Advanced Science, EarlyView.
ABSTRACT Predicting soil carbon dynamics under warming is constrained by limited understanding of microbial thermal adaptation, particularly whether microbial carbon use efficiency (CUE) can adapt to warming and how plant diversity modulates this response. Using soils from a natural tree species diversity gradient in a subtropical forest, we combined a
Pengpeng Duan, Changqing Ye, Xinyi Yang, Chaoqun Wang, Wolfgang Wanek, Jian‐sheng Ye, Hongzhao Yuan, Hu Du, Kongcao Xiao, Xunyang He, Kelin Wang, Dejun Li   +11 more
wiley   +1 more source

Inhibitory Mechanism of Camellianin A against α-Glucosidase: In Vitro and Molecular Simulation Studies

Foods
α-Glucosidase is an important target for type II diabetes treatment, and the search for natural α-glucosidase inhibitors is currently a hot topic in functional food research.
Jinze Jia, Lu Bai, Yuzhen Chen, Benguo Liu   +3 more
doaj   +1 more source

Binding Interaction of Betulinic Acid to α-Glucosidase and Its Alleviation on Postprandial Hyperglycemia

Molecules, 2022
Inhibiting the intestinal α-glucosidase can effectively control postprandial hyperglycemia for type 2 diabetes mellitus (T2DM) treatment. In the present study, we reported the binding interaction of betulinic acid (BA), a pentacyclic triterpene widely ...
Shaodan Chen, Bing Lin, Jiangyong Gu, Tianqiao Yong, Xiong Gao, Yizhen Xie, Chun Xiao, Janis Yaxian Zhan, Qingping Wu   +8 more
doaj   +1 more source

MOESM6 of Production of a high-efficiency cellulase complex via β-glucosidase engineering in Penicillium oxalicum

, 2016
Additional file 6: Table S1. Primers used in this study.
Yao, Guangshan, Wu, Ruimei, Kan, Qinbiao, Gao, Liwei, Liu, Meng, Yang, Piao, Du, Jian, Li, Zhonghai, Qu, Yinbo   +8 more
openaire   +1 more source

Synthesis and Evaluation of 1,3,5-Triaryl-2-Pyrazoline Derivatives as Potent Dual Inhibitors of Urease and α-Glucosidase Together with Their Cytotoxic, Molecular Modeling and Drug-Likeness Studies

ACS Omega, 2022
In the present work, a concise library of 1,3,5-triaryl-2-pyrazolines (2a–2q) was designed and synthesized by employing a multistep strategy, and the newly synthesized compounds were screened for their urease and α-glucosidase inhibitory activities.
R. Mehmood, A. Sadiq, Reem I Alsantali, E. Mughal, Meshari A Alsharif, Nafeesa Naeem, Asif Javid, M. Al‐Rooqi, G. Chaudhry, Saleh A Ahmed   +9 more
semanticscholar   +1 more source

Oral Delivery Systems for Food‐Derived Bioactive Peptides: Enhancing Stability, Bioavailability, and Health Benefits

Advanced Science, EarlyView.
Advanced delivery systems—including nanoparticles, nanoemulsions, liposomes, and hydrogels—protect food‐derived bioactive peptides from gastrointestinal degradation and bitterness. These systems enable pH‐responsive release, enhance intestinal absorption, and improve therapeutic efficacy against oxidative stress, metabolic disorders, cancer, and ...
Yu Xu, Fan Li, Runan Zhao, Tao Shu, Weihong Min, Bei‐Wei Zhu   +5 more
wiley   +1 more source

α-Glucosidase and β-glucosidase from psychrotrophic strain arthrobacter sp. C2-2

Czech Journal of Food Sciences, 2005
In this work six psychophilic and psychrotrophic bacterial strains were screened for the presence of different glycosidase activities (α-galactosidase, α-glucosidase, β-glucosidase, α-mannosidase and β-glucuronidase).
Eva Benešová, Michaela Marková, Blanka Králová   +2 more
doaj   +1 more source

MOESM3 of The structural and functional contributions of β-glucosidase-producing microbial communities to cellulose degradation in composting

, 2018
Additional file 3: Figure S3. Differences in the abundance and expression of family 3 β-glucosidase genes from fungi (GH3) in the natural compost and the inoculated compost.
Zang, Xiangyun, Liu, Meiting, Fan, Yihong, Xu, Jie, Xu, Xiuhong, Li, Hongtao   +5 more
openaire   +1 more source