Results 101 to 110 of about 42,943 (266)

MOESM1 of Proof of concept for the simplified breakdown of cellulose by combining Pseudomonas putida strains with surface displayed thermophilic endocellulase, exocellulase and β-glucosidase

, 2016
Additional file 1: Figure S1. Influence of MATE-fusion protein expression on the growth of P. putida. Grey: Cells without protein expression. Black: Cells expressing MATE-BglA (A), MATE-CelA (B) and MATE-CelK (C). Dashed lines depict the starting points of protein expression, which was induced by the addition of 0.2 % l-arabinose.
Iasson Tozakidis, Brossette, Tatjana, Lenz, Florian, Maas, Ruth, Jose, Joachim   +4 more
openaire   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, EarlyView.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Benzonate derivatives of acetophenone as potent α-glucosidase inhibitors: synthesis, structure–activity relationship and mechanism

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
In this article, 23 compounds (6 and 7a–7v) were prepared and evaluated for their in vitro α-glucosidase inhibitory activity. The compounds 7d, 7f, 7i, 7n, 7o, 7r, 7s, 7u, and 7v displayed the α-glucosidase inhibition activity with IC50 values ranging ...
Wen-Jia Dan, Qiang Zhang, Fan Zhang, Wei-Wei Wang, Jin-Ming Gao   +4 more
doaj   +1 more source

Bromelain as the enzyme of the future: A global bibliometric mapping of its applications and emerging trends

Journal of the Science of Food and Agriculture, EarlyView.
Abstract INTRODUCTION Bromelain, a complex mixture of proteolytic enzymes primarily extracted from plants of the Bromeliaceae family, has gained prominence because of its broad industrial applicability, particularly in the food, pharmaceutical and cosmetic sectors.
Genésio José da Silva Neto, Tonny Cley Campos Leite, Mônica Tejo Cavalcanti, Geany Targino Sousa Pedrosa, Rerisson do Nascimento Alves, Amanda Reges de Sena, Mônica Correia Gonçalves   +6 more
wiley   +1 more source

Exploring the inhibitory effect and mechanism of 3,4,5-trihydroxybiphenyl on α-glucosidase: an integrated experimental and computational approach

Frontiers in Pharmacology
3,4,5-Trihydroxybiphenyl (THB) is a naturally occurring compound derived from Sorbus pohuashanensis, primarily reported for its antifungal activity. However, its potential to inhibit α-glucosidase remains unclear.
Ruofan Guo, Ruofan Guo, Guohua Yu, Yuan Li, Youyou Wang, Youyou Wang, Huixia Fan, Shuo Zhang, Chen Wang, Junhui Zhou, Junhui Zhou, Jian Yang, Jian Yang, Feng Gao, Feng Gao, Zhiqiang Luo   +15 more
doaj   +1 more source

Bio‐guided fractionation of (9Z)‐5,8,11‐trihydroxyoctadec‐9‐enoic acid from Abelmoschus sagittifolius root as a potent α‐glucosidase inhibitor: An integrated in vitro and in silico study

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Abelmoschus sagittifolius stands out as a valuable medicinal source for developing functional food targeting type 2 diabetes. This study investigated the α‐glucosidase inhibitory potential of an active fraction obtained from A. sagittifolius roots (ASR), enriched in (9Z)‐5,8,11‐trihydroxyoctadec‐9‐enoic acid (OA), using both enzyme ...
Nguyen Phuong Mai, Nguyen Van Quan, Nguyen Dang Duc, Tran Dang Xuan   +3 more
wiley   +1 more source

Nitrogen Enrichment Enhances Soil Multifunctionality Through Distinct Drivers Across Urban, Suburban, and Rural Forests

Land Degradation &Development, EarlyView.
ABSTRACT The accelerating pace of urban expansion has profoundly reshaped urban–rural ecosystems, altering soil environments and impairing key ecological services. However, the combined impacts of urban expansion and atmospheric nitrogen (N) deposition on soil multifunctionality—the capacity to sustain multiple ecological processes—remain poorly ...
Xu Sun, Xiao Tao, Qingshui Yu, Zhuangzhuang Qian   +3 more
wiley   +1 more source

In Vitro Inhibition of α-Amylase and α-Glucosidase by Different Parts of Amla Plant (Phyllanthus emblica L)

Pharmacology and Clinical Pharmacy Research, 2018
Amla plant (Phyllanthus emblica L) has been empirically used to treat diabetes. The aim of this study was to determine the most potential part of amla plant that can be used as α-glucosidase and α-amylase inhibitors.
Novi I. Fauzi, Maria Ulfah, Syarif Hamdani, Saeful Hidayat   +3 more
doaj  

Alpine Secondary Forest Types Influence Soil Microbial Community Structure and Enzyme Activities on the Eastern Qinghai–Tibet Plateau

Land Degradation &Development, EarlyView.
ABSTRACT Soil microbial communities and enzyme activities influence soil functions and tree growth in ecologically fragile alpine regions. However, differences in soil microbial communities among secondary forests remain poorly understood in the Qinghai–Tibet Plateau.
Qiuyun Fan, Ruoqi Zhang, Yuqing Geng, Yaning Luan, Yuhai Zhang, Yali Yuan   +5 more
wiley   +1 more source

A review on the in vitro and in vivo screening of α-glucosidase inhibitors

Heliyon
As a global metabolic disease, the control and treatment of diabetes have always been the focus of medical research. α-Glucosidase is a key enzyme in regulating blood glucose levels and has important applications in the treatment of diabetes. This review
Guangjuan Pan, Yantong Lu, Zhiying Wei, Yaohua Li, Li Li, Xiaojiao Pan   +5 more
doaj   +1 more source