Results 131 to 140 of about 975,489 (310)

New Perspectives on the Risks of Hydroxylated Polychlorinated Biphenyl (OH-PCB) Exposure: Intestinal Flora α-Glucosidase Inhibition

Toxics
Polychlorinated biphenyls (PCBs) are a group of colorless and odorless environmental pollutants with a wide range of toxic effects. Some PCBs, especially less chlorinated ones, will rapidly undergo phase I metabolism after entering the body, and ...
Guoqiang Qin, Ruoyong Jia, Juntang Xue, Li Chen, Yang Li, Weiming Luo, Xiaomin Wu, Tianfeng An, Zhongze Fang   +8 more
doaj   +1 more source

Comparison in vitro and in silico studies of phenolic acids and flavonoids on α-glucosidase inhibition [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Inhibiting α-glucosidase activity has been proven to regulate hyperglycemia for treating diabetes, particularly type 2 diabetes mellitus (T2DM).
Muhammad Subhan, Kamonpan Sanachai, Bunleu Sungthong, Suthida Datham, Juthamat Ratha, Ploenthip Puthongking   +5 more
doaj   +1 more source

4-Phenylthiazol-1,2,3-triazole derivatives as new potential α-glucosidase and α-amylase inhibitors

Type-2 diabetes mellitus (T2DM) can be managed by targeting carbohydrate hydrolases such as α-glucosidase and α-amylase. In this regard, a new 4-phenylthiazol-benzamide-1,2,3-triazole-N-phenylacetamide scaffold was designed via molecular hybridization ...
Taslimi, Parham, Mahdavi, Mohammad, Doraghi, Fatemeh, Mohammadi-Khanaposhtani, Maryam, Gülçin, İlhami, AKTAŞ, AYDIN, Şenol, İlbilge Merve, Larijani, Bagher, Dadgar, Armin, Ghanbarlou, Mehdi, Sadeghian, Nastaran, Ebrahimi-Rad, Mina, Karimian, Somaye   +12 more
core   +1 more source

Effect of Pretreatment Methods on the Proximate Composition, Antinutritional Factors, Antioxidants Properties, and In Vitro Antidiabetic Activities of Hypsizygus ulmarius

Food Chemistry International, EarlyView.
The effect of pretreatment methods on the proximate content, antinutrient factors, antioxidant, and in vitro antidiabetic activities of elm oyster mushroom was studied. It was observed and statistically concluded that soaking in 0.5% salt solution for 5 min had the least deteriorating effect on the antioxidant and in vitro antidiabetic activities ...
Oluwadamilola Ogunsade, Saka Olasunkanmi Gbadamosi, Tunde Afolabi Morakinyo, Adedayo Olubunmi Adeboye, Akinsola Albert Famuwagun   +4 more
wiley   +1 more source

Rapidly screening of α-glucosidase inhibitors from Dioscorea opposita Thunb. peel based on rGO@Fe3O4 nanocomposites microreactor

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Present study aimed to immobilise the α-glucosidase on suitable supports to construct enzymatic microreactors and their subsequent applicability in efficient inhibitor screening from the Chinese Yam (Dioscorea opposita Thunb.) peel.
Songsong Zhang, Beibei Qiu, Jinhua Zhu, Weiping Hu, Fanyi Ma, M. Z. H. Khan, Xiuhua Liu   +6 more
doaj   +1 more source

MOESM1 of Proof of concept for the simplified breakdown of cellulose by combining Pseudomonas putida strains with surface displayed thermophilic endocellulase, exocellulase and β-glucosidase

, 2016
Additional file 1: Figure S1. Influence of MATE-fusion protein expression on the growth of P. putida. Grey: Cells without protein expression. Black: Cells expressing MATE-BglA (A), MATE-CelA (B) and MATE-CelK (C). Dashed lines depict the starting points of protein expression, which was induced by the addition of 0.2 % l-arabinose.
Iasson Tozakidis, Brossette, Tatjana, Lenz, Florian, Maas, Ruth, Jose, Joachim   +4 more
openaire   +1 more source

Seasonal activity of neutral α-glucosidase.

, 2015
x—arithmetic mean, SD–standard deviationSeasonal activity of neutral α-glucosidase.
Wojciech Nowacki (805466), Julia Kotońska-Feiga (825007), Przemysław Pokorny (825009), Wojciech Dobicki (825008)   +3 more
core   +1 more source

Impact of Sprouting and Brachystegia eurycoma Supplementation on the Functional, Proximate Composition, and Bioactive, Antioxidant, and Enzyme‐Inhibitory Properties of Sorghum Flour

Food Chemistry International, EarlyView.
Sprouting and Brachystegia eurycoma supplementation improved sorghum flour nutrition, antioxidant activity and enzyme inhibition for functional foods. ABSTRACT Sprouting and cereal–legume supplementation are effective strategies for improving the functional, nutritional, and nutraceutical qualities of cereal‐based flour and products.
Khadijat Oluwashola Abdulrazaaq, Emmanuel Anyachukwu Irondi, Emmanuel Oladipo Ajani   +2 more
wiley   +1 more source

Benzonate derivatives of acetophenone as potent α-glucosidase inhibitors: synthesis, structure–activity relationship and mechanism

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
In this article, 23 compounds (6 and 7a–7v) were prepared and evaluated for their in vitro α-glucosidase inhibitory activity. The compounds 7d, 7f, 7i, 7n, 7o, 7r, 7s, 7u, and 7v displayed the α-glucosidase inhibition activity with IC50 values ranging ...
Wen-Jia Dan, Qiang Zhang, Fan Zhang, Wei-Wei Wang, Jin-Ming Gao   +4 more
doaj   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source