Results 111 to 120 of about 976,226 (308)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

IN VITRO STUDIES ON THE ANTIDIABETIC ACTIVITY OF 2-THIOHYDANTOIN USING α-amylase AND α-GLUCOSIDASE [PDF]

, 2019
Objective: The aim of the present study was to investigate the inhibitory effect of 2-thiohydantoin on the enzymes α-amylase and α-glucosidase in vitro as an antidiabetic therapeutic approach to reduce gastrointestinal glucose production.
UMA S, DEVIKA PT
core   +1 more source

Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors

Molecules, 2017
A novel series of 2-substituted-4,6-diarylpyrimidines 6a–6t has been synthesized, characterized by 1H-NMR, 13C-NMR and HRMS, and screened for in vitro α-glucosidase inhibitory activity.
Zipeng Gong, Zhenzhen Xie, Jie Qiu, Guangcheng Wang   +3 more
doaj   +1 more source

Genistein, a soy isoflavone, is a potent α-glucosidase inhibitor [PDF]

, 2001
Genistein is an isoflavone that is known to be contained in soybean. It was proved that genistein plays a pivotal role in homeostasis in the human body. In the course of screening for useful α-glucosidase inhibitors, we isolated and identified genistein ...
Dong-Sun Lee, Lee, Sang-Han, Sang Han Lee, Sang-Han Lee, Dong Sun Lee, Lee, Dong-Sun   +5 more
core   +1 more source

Stage‐Dependent Metabolic Reprogramming Drives a Self‐Organizing Microbial Network During Shanxi Aged Vinegar

Food Bioengineering, EarlyView.
Metabolic shifts from growth to stress adaptation in Shanxi aged vinegar fermentation link flavor maturation and microbial cooperation, and Lactobacillus and Acetobacter form a self‐organizing metabolic network through division of labor. ABSTRACT Acetic acid fermentation (AAF) is a vital stage in the production of Shanxi aged vinegar (SAV), during ...
Yanfang Wu, Jing Liu, Dantong Liu, Menglei Xia, Jia Song, Yu Zheng, Min Wang   +6 more
wiley   +1 more source

Extraction and Characterization of α -Amylase and α-Glucosidase Enzymes for Ethanol Preparation [PDF]

, 2020
In the research work, two enzymes (α -amylase and α-glucosidase) were extracted from germinated wheat grains and ungerminated flint corn by ammonium sulphate precipitation method for the bioethanol preparation.
Khin Moh Moh Hlaing, Dr, Ni Ni Aung, Dr, Aung Kyaw Moe, Mya Hnin Aye Khaing, Dr   +3 more
core   +1 more source

Constituents From the Flowers of Viburnum macrocephalum f. macrocephalum and Their α-Amylase and α-Glucosidase Inhibitory Activities. [PDF]

Chem Biodivers
Two new cadinane‑type sesquiterpenes, viburetones A and B, were isolated from Viburnum macrocephalum flowers, marking the first cadinane skeletons in this genus. Viburetone A showed dual α‑amylase and α‑glucosidase inhibition comparable to acarbose, and docking clarified its binding.
Chen YJ, Zhou HJ, Zhu XJ, Chen J, Shao JH, Zhao CC.   +5 more
europepmc   +2 more sources

Localisation of β-glucosidase inTrichoderma reeseicell walls with immunoelectron microscopy [PDF]

FEMS Microbiology Letters, 1986
Using ferritin-conjugated antibodies as an electron microscopic marker, β-glucosidase was localized within the cell walls of the imperfect fungus Trichoderma reesei QM9414. With different states of cell wall degradation obtained with a cell wall-lysing culture filtrate of Micromonospora chalcea, β-glucosidase was mainly detected within the outer ...
openaire   +1 more source

New anti-α-Glucosidase and Antioxidant Ingredients from Winery Byproducts: Contribution of Alkyl Gallates

, 2023
Wine-making activity entails the production of solid and semisolid byproducts (grape stems and pomace and wine lees) that negatively impact the environment and industrial sustainability.
Domínguez-Perles, Raúl, García-Viguera, Cristina, Medina Escudero, Sonia   +2 more
core   +1 more source

Fermentation‐Induced Modulation of Polyphenolic Contents and Medicinal Activities in Annona squamosa Seeds

Food Chemistry International, EarlyView.
The study compared the medicinal activities of polyphenols from fermented and unfermented seeds of Annona squamosa. The polyphenols were extracted and subjected to standard analysis. The major phenolic components of the fermented polyphenols and the unfermented polyphenols were found to be 4‐hydroxybenzoic and 4‐hydroxyphenylacetic acid, respectively ...
Shola Hezekiah Awojide, Abayomi Gideon Adeyemo, Christianah Dare, Oluseye Oladapo Abiona, Adedayo Olubunmi Adeboye, Omolara Oladipo‐Olalekan, Aminat Adebola Adeyemo, Yemisi Elizabeth Asibor, Emmanuel Oluwafemi Adeniyi, Bunmi Regina Bankole, Ezekiel Olumide Fadunmade   +10 more
wiley   +1 more source