Results 121 to 130 of about 1,767,553 (166)

Comparative study of inhibition mechanisms of structurally different flavonoid compounds on α-glucosidase and synergistic effect with acarbose.

Food Chemistry, 2021
Flavonoid compounds have anti-diabetic activity, which can control blood glucose levels by inhibiting α-glucosidase activity. In this paper, the inhibition mechanisms between four flavonoid compounds and α-glucosidase were studied by multispectroscopic ...
Jichen Yang, Xiaoli Wang, Chuanying Zhang, Lun Ma, Tao Wei, Yajing Zhao, Xin Peng   +6 more
semanticscholar   +1 more source

Lumi-HOF@Tb as Probes for Multiple Ratiometric Fluorescence and Chemiluminescence Sensing of α-Glucosidase.

Analytical Chemistry, 2022
The innovative assembly of luminescent hydrogen-bonded organic frameworks (HOFs) into multifunctional optical sensors is of great significance for developing advanced materials.
Haiyan Li, Shangqing Zhang, Mingli Chen, Jianhua Wang   +3 more
semanticscholar   +1 more source

Inhibition mechanism of ferulic acid against α-amylase and α-glucosidase.

Food Chemistry, 2020
The inhibitory mechanisms of ferulic acid against α-amylase and α-glucosidase were investigated by enzyme kinetic analysis, circular dichroism (CD), Fourier-transform infrared (FT-IR) spectroscopy, fluorescence quenching and molecular docking.
Yuxue Zheng, Jinhu Tian, Wenhan Yang, Shiguo Chen, Donghong Liu, Haitian Fang, Huiling Zhang, Xingqian Ye   +7 more
semanticscholar   +1 more source

Performance of β-Glucosidase produced by Ganoderma lucidum using Waste Substrate as Carbon Source

Journal of Biochemistry, Microbiology and Biotechnology, 2013
Oil palm empty fruit bunch (OPEFB) was used for the production of β-glucosidase by Ganoderma lucidum in submerged fermentation. The activity of β-glucosidase had shown an improvement by going from pH 4 to 6 and declined towards alkaline pH. The highest activity (47.75 U/mL) was obtained at pH 6 with 2.0 mm size of substrate’s particle.
Nur Haziqah Aniyah Salihan, Arbakariya Ariff, Mohd Rafein Zakaria, Suraini Abd-Aziz, Md Noor Bd Wahab, Helmi Wasoh   +5 more
openaire   +1 more source

Chemical structure and inhibition on α-glucosidase of polysaccharides from corn silk by fractional precipitation.

Carbohydrate Polymers, 2021
Aimed to explore different corn silk polysaccharide (CSP) fractions derived by ethanol precipitation on the physicochemical properties and biological activities, four fractions (CSP20, CSP40, CSP60, and CSP80) were obtained.
Yanan Jia, Zihan Xue, Yajie Wang, Yangpeng Lu, Ruilin Li, Nannan Li, Qirou Wang, Min Zhang, Min Zhang, Haixia Chen   +9 more
semanticscholar   +1 more source

Recent Advances of α-Glucosidase Inhibitors: A Comprehensive Review.

Current Topics in Medicinal Chemistry, 2022
BACKGROUND Diabetes mellitus (DM) is a critical health issue prevailing in nearly half a billion people worldwide. It is one of the most threatening metabolic diseases. Type 2 DM is caused due to insulin resistance and accounts for 90% of diabetes cases.
Ahsas Goyal, N. Agrawal, Manisha Sharma, Shikha Singh   +3 more
semanticscholar   +1 more source

Novel Bis-Schiff's base derivatives of 4-nitroacetophenone as potent α-glucosidase agents: Design, synthesis and in silico approach.

Bioorganic chemistry (Print), 2022
Bis-Schiff's base derivatives of 4-nitroacetophenone (1-18) were synthesized in good yields by reacting hydrazone of 4-nitroacetophenone with substituted aldehydes and ketones with catalytic amount of acetic acid.
A. Alam, Mumtaz Ali, A. Latif, N. Rehman, Samina Saher, Zainab, Faryal, Ajmal Khan, S. Ullah, Obaid Ullah, S. Halim, F. Sani, A. Al‐Harrasi, Manzoor Ahmad   +13 more
semanticscholar   +1 more source

The inhibitory mechanism of chlorogenic acid and its acylated derivatives on α-amylase and α-glucosidase.

Food Chemistry, 2021
Due to the poor lipophilicity of chlorogenic acid (CA), five CA derivatives (C2-CA, C4-CA, C6-CA, C8-CA, and C12-CA) with different lipophilicities were synthesized using acylation catalyzed by lipase in present study.
Shang-Sheng Wang, Yue Li, Dejian Huang, Shang-wei Chen, Yong-mei Xia, Song Zhu   +5 more
semanticscholar   +1 more source

In vitro and in vivo inhibitory effect of anthocyanin-rich bilberry extract on α-glucosidase and α-amylase

, 2021
The inhibition of glycosidase activity is regarded as an effective treatment for diabetes mellitus. Bilberry (Vaccinium myrtillus L.) fruit has a high content of anthocyanins with various biological activities.
Yanglin Ji, Dong Liu, Yan Jin, Juan Zhao, Jiang Zhao, Heyu Li, Liwei Li, Huan Zhang, Hao Wang   +8 more
semanticscholar   +1 more source

Extraction, identification, and molecular mechanisms of α-glucosidase inhibitory peptides from defatted Antarctic krill (Euphausia superba) powder hydrolysates.

International Journal of Biological Macromolecules
The objective of this study was to explore the potential of Antarctic krill-derived peptides as α-glucosidase inhibitors for the treatment of type 2 diabetes.
Kewei Zheng, Yuanyuan Wu, Qingfei Dai, Xiaojun Yan, Yu Liu, Di Sun, Zhongjie Yu, Shuoqi Jiang, Qingbao Ma, Wei Jiang   +9 more
semanticscholar   +1 more source