Results 241 to 250 of about 976,226 (308)

Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease

American Journal of Hematology, Volume 101, Issue 9, Page 2197-2213, September 2026.
ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain, Noffar Bar, Lilu Guo, Katherine Klinger, Punita Gupta, Atta Ur Rahman, Ruhua Yang, Yanhong Deng, Natalia Neparidze, Shiny Nair, Pramod K. Mistry   +10 more
wiley   +1 more source

DeepSAT + SMART-Driven Identification of Diterpene Glycosides with α‑Glucosidase Inhibitory Activities from the Rhizomes of a Crop Plant, <i>Isodon suzhouensis</i>. [PDF]

ACS Omega
Chen J, Wang DD, Guo Z, Li S, Li JY, Ren FC, Liu XS, Shen CP.   +7 more
europepmc   +1 more source

Diagnostic Odyssey of Atypical Long‐Chain 3‐Hydroxyacyl‐CoA Dehydrogenase Deficiency (LCHADD) Explained by Three Allelic Products From Two Pathogenic Variants

American Journal of Medical Genetics Part A, Volume 200, Issue 9, Page 2128-2135, September 2026.
ABSTRACT Long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency (LCHADD) is an autosomal recessive mitochondrial defect of long‐chain fatty acid β‐oxidation, caused by biallelic pathogenic variants in HADHA or HADHB. We report a 22‐year‐old male with an atypically mild presentation of LCHADD who was referred to the Undiagnosed Diseases Network (UDN ...
Yutaka Furuta, Lynette C. Rives, T. Andrew Burrow, Thomas A. Cassini, Rory J. Tinker, Amy K. Robertson, Kimberly M. Ezell, Rizwan Hamid, Joy D. Cogan, John A. Phillips III   +9 more
wiley   +1 more source

Potent and selective α-glucosidase inhibition by coumarin-triazole conjugates: design, <i>in vivo</i> evaluation, and computational insights. [PDF]

RSC Adv
Sadeghi Moghadam M, Bayati B, Peytam F, Norouzbahari M, Gülcan HO, Mojtabavi S, Ghasemi F, Sadat-Ebrahimi SE, Barazandeh Tehrani M, Sheibani V, Firoozpour L, Foroumadi A.   +11 more
europepmc   +1 more source

From Traditional Spice to Functional Ingredient: Phenolic Profile and Bioactive Properties of Sicilian Rhus coriaria L. Fruit

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The phenolic composition of Rhus coriaria fruits has been comprehensively characterized and linked to a variety of biological activities, including antioxidant, anti‐glycation, enzyme‐inhibitory, and cytoprotective effects. These findings highlight the functional potential of Sicilian sumac as a valuable source of health‐promoting phytochemicals ...
Katia Arena, Donatella Ambroselli, Roberto Laganà Vinci, Luigi Mondello, Luca Santi, Laura Dugo, Paola Dugo   +6 more
wiley   +1 more source

Endoplasmic reticulum-resident α-glucosidase II drives non-small cell lung cancer progression via regulation of secretory glycoproteins. [PDF]

JCI Insight
Wang S, Ding N, Chen A, Cardin D, Xu Y, Grimley K, Russell WK, Xu J, Kurie JM, Xiao GY, Tan X.   +10 more
europepmc   +1 more source

Sesquiterpene‐Rich Essential Oil From Magnolia officinalis Stem Bark: Chemical Composition, Biological Activities, and In Silico Approach

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The essential oil from Magnolia officinalis (M. officinalis) stem bark, rich in sesquiterpenes, exhibited multiple bioactivities including cytotoxic, antioxidant, α‐glucosidase inhibitory, anti‐inflammatory, and antimicrobial effects, which were further supported by molecular docking analysis.
Nguyen Thi Kim Thanh, Phan Hong Minh, Huynh Thi Ngoc Ni, Tran Quang Hai, Le The Hoai, Le Ba Vinh, Pham Minh Quan, Nguyen Dinh Luyen, Ninh The Son   +8 more
wiley   +1 more source

From simulated digestion to α-glucosidase inhibition: The metabolic fate of wine hydroxycinnamic acids. [PDF]

Curr Res Food Sci
Liu Y, Li H, Liu G, Zhao Y, Luo Y, Xu W, Song S, Han F.   +7 more
europepmc   +1 more source

Synthesis, Characterization, and Multifunctional Bioactivity of ZnO/CuO@Amoxicillin Nanocomposites: A Synergistic Nano‐Platform With Potent Antioxidant, Anti‐Inflammatory, Antidiabetic, and Anti‐Cholinesterase Activities

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
ZnO/CuO@amoxicillin nanocomposite, synthesized via sol–gel route, demonstrates exceptional multifunctional performance. It strongly inhibits α‐amylase and α‐glucosidase, effectively suppresses inflammation, and exhibits superior antioxidant activity surpassing ascorbic acid.
Hocine Sadam Nesrat, Abdelatif Aouadi, Ibtissam Laib, Salah Eddine Laouini, Abderrhmane Bouafia, Djamila Hamada Saoud, Halima Zidane, Hafidha Terea, Mahmood M. S. Abdullah, Tomasz Trzepieciński, Dalila Saidane‐Mosbahi   +10 more
wiley   +1 more source

Design, <i>in Vitro</i> Biological Activities and Molecular Dynamics Simulations of Novel Chalcone and Pyrazole Derivatives Targeting α‑Glucosidase and PPAR‑γ as Antidiabetic Agents. [PDF]

ACS Omega
Kurşun Aktar BS, Taşdemir D, Sağlam E, Kaya S, Yılmaz GT, Şahin Yağlioğlu A, Oruç-Emre EE.   +6 more
europepmc   +1 more source