Results 261 to 270 of about 976,226 (308)

Endophytic Fungi Natural Factories of Novel Bioactive Compounds

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review provides a systematic analysis of 242 natural products isolated from 42 genera of endophytic fungi, highlighting their remarkable structural diversity and broad spectrum of biological activities . ABSTRACT Endophytic fungi represent a prolific and chemically diverse source of novel specialized metabolites with significant pharmacological ...
Dilmurod Murodullayev, Jakhongir Movlanov, Liu Wei, Wei Liu, Maksud Isokov, Santosh Kumar Bose, Fazliddin Kobilov, Zamira Djumayeva, Buston Islamov, Jamila Sherkulova, Zafar Matyakubov, Muniskhon Meylieva, Munisa Ergasheva, Diyor Abduraxmanov, Guozheng Huang, Hongchen Jiang, Kakhramon Davranov, Guohui Pan, Nigora Rustamova   +18 more
wiley   +1 more source

Inhibition mechanism and behaviour of wedelolactone against α-glucosidase. [PDF]

J Enzyme Inhib Med Chem
Zhang J, Zhao M, Wu F, Shi Z, Xie R.
europepmc   +1 more source

New insights in pediatric metabolic medicine: pathogenesis of cholesterol biosynthesis defects and innovative therapies for Pompe disease [PDF]

, 2007
Rossi, Emiliano
core  

Classification, Structure–Activity Relationship, and Anti‐Osteoarthritis Mechanism of Natural Flavonoids

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Natural product flavonoids have a multi‐target therapeutic intervention effect on osteoarthritis. They promote autophagy and cartilage synthesis while alleviating oxidative stress, inhibiting inflammation, and inhibiting matrix degradation. By restoring OPG/RANKL balance and regulating bone metabolism, these compounds synergistically delay the ...
Haibin Wang, Shuqi Zheng, Chunlei Hua, Wanze Feng, Zengxia Liu, Yanhong Sun, Minhui Li   +6 more
wiley   +1 more source

Content Differences of Active Ingredients in Different Flower Colors of <i>Carthamus tinctorius</i> L. and Their α-Glucosidase Inhibitory Effects Based on Network Pharmacology and Molecular Docking. [PDF]

Curr Issues Mol Biol
Huang F, Zhao W, Wang S, Li J, Zeng L, Zhu J.   +5 more
europepmc   +1 more source

Fatty Acid Composition of Fixed Oil of Linum strictum and Its Antibiofilm, Anticoagulant, and α‐Amylase Inhibitory Effects–In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Chemical composition, in vitro biological activity and in silico molecular docking of fixed oil of Linum strictum. ABSTRACT The present study investigated the fatty acid composition of Linum strictum seed oil and evaluated its antibacterial, antibiofilm, anticoagulant, and α‐amylase inhibitory activities.
Hayet Edziri, Pooja Bargali, Marwa Melliti, Hasan Aljohi, Mohammad NasserAlkhrayef, Rim Gtari, Marcello Iriti, Ravendra Kumar, Ibrahim O. Alanazi   +8 more
wiley   +1 more source

Prenylated Isoflavones Originating from East African Medicinal Plants Selectively Modulate the α-Glucosidase from <i>Saccharomyces cerevisiae</i>. [PDF]

J Nat Prod
Lüersen K, Neuber F, Sperlich E, Kelling A, von Chamier-Gliszczinski S, Greese J, Demissie TB, Schmidt B, Rimbach G, Nchiozem-Ngnitedem VA.   +9 more
europepmc   +1 more source

Evidence‐based ranking of diabetes prevention in prediabetes: A comprehensive network meta‐analysis of 378 randomised controlled trials

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
• We analysed 378 RCTs (113 122 participants). • Dual GLP‐1/GIP agonists reduced T2D risk by 90%, followed by GLP‐1 agonists (74%) and metformin plus ILI (73%). • Physical activity and ILI improved glycaemic markers at 12 months. Lifestyle benefits peaked at 3–6 months, whereas metformin effects appeared longer‐lasting. • Lifestyle modifications remain
Bucur Maria, Eperjesi Orsolya, Panait Robert Iulian, Topala Mihaela, Babakhani Avin Aphrodite, Rancz Anett, Kói Tamás, Fazekas Karen, Obeidat Mahmoud, Papp Renáta, Ferdinándy Péter, Szentesi Andrea, Gheorghe Cristian, Hegyi Peter, Bunduc Stefania   +14 more
wiley   +1 more source

Solacanin C, a new pregnane steroid from <i>Solanum torvum</i> fruits: structural elucidation, potent α-glucosidase inhibition, and <i>in silico</i> ADMET profiling. [PDF]

RSC Adv
Le TH, Han Le NT, Dang PH, Phan TT, Nguyen PT, Nguyen HX, Do TNV, Thi Nguyen MT.   +7 more
europepmc   +1 more source

Sulfonamide‐Based 2‐Amino‐1,3,4‐Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Gülnur Arslan Karahan, Başak Gökçe, Muhammed Tilahun Muhammed, Emre Kadir Ayan, Azime Berna Özçelik   +4 more
wiley   +1 more source