Synthesis, Biological Evaluation, and Computational Studies of Phenolic <i>N</i>-Acetylglucosamine Glycosides as α-Glucosidase Inhibitors. [PDF]
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Soil Microbial Assembly Mirrors a Savanna Mosaic Amid Plant Invasion and Soil Disturbance
Grasslands and woody patches supported distinct soil and microbial assemblages, consistent with differences in vegetation inputs and nutrient regimes. Grasslands exhibited relatively simple assembly patterns, with plant diversity closely associated with soil nutrients and comparatively homogeneous microbial communities.
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Safety evaluation of the food enzyme glucan 1,4-α-glucosidase from the non-genetically modified <i>Aspergillus niger</i> strain AE-GN. [PDF]
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New Endiandric Acid from <i>Beilschmiedia lumutensis</i> and Their Molecular Docking Study as α-amylase and α-glucosidase Inhibitors. [PDF]
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Therapeutic Innovation from Plant-Derived Thai Herbal Extracts: α-Glucosidase Inhibitory Activity, Mechanistic Insights and Formulation Potential of the Selected Thai Rejuvenation Remedy. [PDF]
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Comprehensive Phytopharmacological Profiling of <i>Polygonum aviculare</i> L.: Antioxidant, Anti-Inflammatory, and α-Glucosidase Inhibitory Activities of Bioactive Constituents with Molecular Docking and In Silico Drug-Likeness Analysis. [PDF]
Lee YS, Li SM, Chen HJ, Chen JJ.
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Molecular docking, DFT analysis, pharmacokinetic profiling and MD simulation of Ilex aquifolium L. flavonoids as potential α-glucosidase predicted inhibitors for diabetes. [PDF]
Alnajeebi AM.
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A Computational Comparative study of α-Glucosidase enzyme Divergence
Journal of Applied Bioinformatics & Computational Biology, 2015A Computational Comparative study of α-Glucosidase enzyme Divergence α-Glucosidase (α-Gls) enzymes have a crucial role in digestion of carbohydrates and biosynthesis of glycoproteins. Theses enzymes hydrolyze terminal glycosidic bonds and release α-glucose from the substrate chain. They are found in prokaryotic cells, plants and mammalian tissues such
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Journal of Biochemistry, Microbiology and Biotechnology, 2013Oil palm empty fruit bunch (OPEFB) was used for the production of β-glucosidase by Ganoderma lucidum in submerged fermentation. The activity of β-glucosidase had shown an improvement by going from pH 4 to 6 and declined towards alkaline pH. The highest activity (47.75 U/mL) was obtained at pH 6 with 2.0 mm size of substrate’s particle.
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ABSTRACT: A therapeutic approach for treating diabetes is to decrease the post-prandial hyperglycaemia. This is done by retarding the absorption of glucose through the inhibition of the carbohydrate hydrolyzing enzymes, α-amylase and α-glucosidase, in the digestive tract.
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