Results 181 to 190 of about 2,753,652 (191)

Recent Advances of α-Glucosidase Inhibitors: A Comprehensive Review.

Current Topics in Medicinal Chemistry, 2022
BACKGROUND Diabetes mellitus (DM) is a critical health issue prevailing in nearly half a billion people worldwide. It is one of the most threatening metabolic diseases. Type 2 DM is caused due to insulin resistance and accounts for 90% of diabetes cases.
Ahsas Goyal, N. Agrawal, Manisha Sharma, Shikha Singh   +3 more
semanticscholar   +1 more source

Novel Bis-Schiff's base derivatives of 4-nitroacetophenone as potent α-glucosidase agents: Design, synthesis and in silico approach.

Bioorganic chemistry (Print), 2022
Bis-Schiff's base derivatives of 4-nitroacetophenone (1-18) were synthesized in good yields by reacting hydrazone of 4-nitroacetophenone with substituted aldehydes and ketones with catalytic amount of acetic acid.
A. Alam, Mumtaz Ali, A. Latif, Najeeb Ur Rehman, Samina Saher, Zainab, Faryal, Ajmal Khan, S. Ullah, Obaid Ullah, S. Halim, F. Sani, A. Al-Harrasi, Manzoor Ahmad   +13 more
semanticscholar   +1 more source

Extraction, identification, and molecular mechanisms of α-glucosidase inhibitory peptides from defatted Antarctic krill (Euphausia superba) powder hydrolysates.

International Journal of Biological Macromolecules
The objective of this study was to explore the potential of Antarctic krill-derived peptides as α-glucosidase inhibitors for the treatment of type 2 diabetes.
Kewei Zheng, Yuanyuan Wu, Qingfei Dai, Xiaojun Yan, Yu Liu, Di Sun, Zhongjie Yu, Shuoqi Jiang, Qingbao Ma, Wei Jiang   +9 more
semanticscholar   +1 more source

Inhibition mechanisms of α-glucosidase by eight catechins: Kinetic, molecular docking, and surface plasmon resonance analysis.

International Journal of Biological Macromolecules
α-Glucosidase is considered to be one of the effective targets for the treatment of type 2 diabetes. This study examined the inhibitory mechanisms of eight catechins on α-glucosidase, including both the free forms (C, EC, GC, EGC) and esterified forms ...
Rui Zhang, Yi-Hua Zhang, Tian Yu, Zhenyuan Zhang, Yixia Chen, Zhaoqiang Jiang, Meng Meng, Min Zhang, Jia-Ping Zhou   +8 more
semanticscholar   +1 more source

The inhibitory mechanism of chlorogenic acid and its acylated derivatives on α-amylase and α-glucosidase.

Food Chemistry, 2021
Due to the poor lipophilicity of chlorogenic acid (CA), five CA derivatives (C2-CA, C4-CA, C6-CA, C8-CA, and C12-CA) with different lipophilicities were synthesized using acylation catalyzed by lipase in present study.
Shang-Sheng Wang, Yue Li, Dejian Huang, Shang-Wei Chen, Yong-Mei Xia, Song Zhu   +5 more
semanticscholar   +1 more source

In vitro and in vivo inhibitory effect of anthocyanin-rich bilberry extract on α-glucosidase and α-amylase

, 2021
The inhibition of glycosidase activity is regarded as an effective treatment for diabetes mellitus. Bilberry (Vaccinium myrtillus L.) fruit has a high content of anthocyanins with various biological activities.
Yanglin Ji, Dong Liu, Yan Jin, Juan Zhao, Jiang Zhao, Heyu Li, Liwei Li, Huan Zhang, Hao Wang   +8 more
semanticscholar   +1 more source

Thiazolidine-2,4-dione derivatives as potential α-glucosidase inhibitors: Synthesis, inhibitory activity, binding interaction and hypoglycemic activity.

Bioorganic chemistry (Print)
Mengyue Li, Jinping Sun, Bingwen Liang, Xiaofeng Min, Jin-Hui Hu, Rihui Wu, Xue-Tao Xu   +6 more
semanticscholar   +1 more source

Structural requirements of flavonoids for the selective inhibition of α-amylase versus α-glucosidase.

Food Chemistry, 2021
Jongbin Lim, M. Ferruzzi, B. Hamaker
semanticscholar   +1 more source

Novel sulfonyl hydrazide based β-carboline derivatives as potential α-glucosidase inhibitors: design, synthesis, and biological evaluation

Molecular diversity
Jinping Sun, Di Xiao, Ming Lang, Xue-Tao Xu   +3 more
semanticscholar   +1 more source

A facile approach synthesis of benzoylaryl benzimidazole as potential α-amylase and α-glucosidase inhibitor with antioxidant activity.

Bioorganic chemistry (Print), 2021
L. Aroua, Hind R. Almuhaylan, F. Alminderej, S. Messaoudi, Sridevi Chigurupati, Suliman Al-mahmoud, Mohammed H Hamdoon   +6 more
semanticscholar   +1 more source