Results 81 to 90 of about 2,753,652 (191)

Antioxidant and α-glucosidase inhibitiory activity of Cercis chinensis flowers

, 2020
Antioxidant and α-glucosidase inhibitiory active compounds of Cercis chinensis flowers were investigated with bio-assay guiding method. Ethyl acetate fraction (CLEa) and n-butanol fraction (CLBu) exhibited antioxidant and α-glucosidase inhibitiory ...
Jinfeng Wei, Li Zhou, Wenyi Kang, Zhenhua Liu, Lili Cui, Juanjuan Zhang   +5 more
core   +1 more source

Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors

Scientific Reports
α-Glucosidase inhibitors have emerged as crucial agents in the management of type 2 diabetes mellitus. In the present study, a new series of coumarin-linked 2-phenylbenzimidazole derivatives 5a–m was designed, synthesized, and evaluated as anti-α ...
Mina Sadeghi Ganjeh, Ali Mazlomifar, Ashraf Sadat Shahvelayti, Shiva Khalili Moghaddam   +3 more
doaj   +1 more source

Cloning and Expression of Marine α-Glucosidase and Its Preparation of High Purity Panose

Shipin gongye ke-ji
Panose is iso-malto-oligosaccharide contained α-1,6 glycosidic bonds, and α-glucosidase is the key enzyme to produce panose. In this study, the α-glucosidase gene in deep-sea hydrothermal vents thermophilic archaea Thermococcus siculi HJ21 was ...
Yiqun YU, Luzhou XUE, Hao NI, Lei JIANG, Xinxin KANG, Saikun PAN, Shujun WANG   +6 more
doaj   +1 more source

Inhibitory Mechanism of Aloe Emodin on α-Glucosidase and Synergistic Effect with Acarbose [PDF]

Shipin Kexue
In order to investigate the interaction between aloe emodin and α-glucosidase, enzyme kinetics, ultraviolet (UV) spectroscopy, infrared (IR) spectroscopy and fluorescence spectroscopy were employed to investigate the inhibitory mechanism of aloe emodin ...
QIN Chaofeng, LI Jiao, HAO Jingwen, BU Yaqin, LI Sheng, CHEN Naidong
doaj   +1 more source

Kinetics of Hypoglycemic α-Glucosidase Inhibitory Protein

, 2018
The activity of a-glucosidase enzyme (EC 3.2.1.20) was inhibited by 40.3% by an extracellular inhibitory protein which isolated from the culture filtrate of Aspergillus brasiliensis ATCC-16404. The maximum activity of this protein and fungal mycelial dry
Fahad A. Al-Dhabaan, Fahad Al-Dhabaan
core   +1 more source

Molecular dynamics simulations reveal the inhibitory mechanism of Withanolide A against α-glucosidase and α-amylase

, 2023
Diabetes mellitus (DM) is a global chronic disease characterized by hyperglycemia and insulin resistance. The unsavory severe gastrointestinal side-effects of synthetic drugs to regulate hyperglycemia have warranted the search for alternative treatments ...
Mohd Hayrie, Mohd Hatta, Oyewusi, Habeebat Adekilekun, Safi, Sher Zaman, Kalaivani, Batumalaie, Wu, Yuan Seng *, Roswanira, Abdul Wahab   +5 more
core   +1 more source

α‑Glucosidase and PTP-1B Inhibitors from Malbranchea dendritica

ACS Omega, 2021
Daniela Rebollar-Ramos, Berenice Ovalle-Magallanes, Juan Francisco Palacios-Espinosa, Martha Lydia Macías-Rubalcava, Huzefa A. Raja, Martín González-Andrade, Rachel Mata   +6 more
doaj   +1 more source

IN VITRO STUDIES ON THE ANTIDIABETIC ACTIVITY OF 2-THIOHYDANTOIN USING α-amylase AND α-GLUCOSIDASE [PDF]

, 2019
Objective: The aim of the present study was to investigate the inhibitory effect of 2-thiohydantoin on the enzymes α-amylase and α-glucosidase in vitro as an antidiabetic therapeutic approach to reduce gastrointestinal glucose production.
UMA S, DEVIKA PT
core   +1 more source

Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors

Molecules, 2017
A novel series of 2-substituted-4,6-diarylpyrimidines 6a–6t has been synthesized, characterized by 1H-NMR, 13C-NMR and HRMS, and screened for in vitro α-glucosidase inhibitory activity.
Zipeng Gong, Zhenzhen Xie, Jie Qiu, Guangcheng Wang   +3 more
doaj   +1 more source

Extraction and Characterization of α -Amylase and α-Glucosidase Enzymes for Ethanol Preparation [PDF]

, 2020
In the research work, two enzymes (α -amylase and α-glucosidase) were extracted from germinated wheat grains and ungerminated flint corn by ammonium sulphate precipitation method for the bioethanol preparation.
Khin Moh Moh Hlaing, Dr, Ni Ni Aung, Dr, Aung Kyaw Moe, Mya Hnin Aye Khaing, Dr   +3 more
core   +1 more source