Results 61 to 70 of about 2,753,652 (191)

Evaluation of cannabidiol’s inhibitory effect on alpha-glucosidase and its stability in simulated gastric and intestinal fluids

Journal of Cannabis Research, 2021
Objective Cannabidiol (CBD) has been reported to have anti-diabetic effects in pre-clinical and clinical studies but its inhibitory effects on α-glucosidase, a carbohydrate hydrolyzing enzyme, remain unknown. Herein, we evaluated CBD’s inhibitory effects
Hang Ma, Huifang Li, Chang Liu, Navindra P. Seeram   +3 more
doaj   +1 more source

and α-Glucosidase Inhibitory Activity of Perfoliatin a from

Natural Product Communications, 2019
As part of our effort to discover new α-glucosidase inhibitors from natural sources, it was found that an aqueous extract from Melampodium perfoliatum (Cavanilles) Kunth (Asteraceae) inhibited the activity of rat-intestinal α-glucosidases in a ...
Laura Flores-Bocanegra, Rafael Torres-Colín, Martin González-Andrade, José S. Calderón, Rachel Mata   +4 more
doaj   +1 more source

Glucosidase-Catalyzed Hydrolysis of α-d-Glucopyranosyl Pyridinium Salts:  Kinetic Evidence for Nucleophilic Involvement at the Glucosidation Transition State

, 2016
Kinetic isotope effects (KIEs) on the yeast α-glucosidase-catalyzed hydrolysis of two α-d-glucopyranosyl pyridinium salts were measured at 25 °C and pH = 6.8. The measured KIEs on kcat for the 2H-2, 13C-1, and 15N-1‘ labeled substrates α-d-glucopyranosyl
Xicai Huang (2676652), Kelly S. E. Tanaka (2409535), Andrew J. Bennet (1755919)   +2 more
core   +1 more source

Inhibitory mechanism of phenolic compounds in rapeseed oil on α-amylase and α-glucosidase: Spectroscopy, molecular docking, and molecular dynamic simulation.

Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, 2022
Developing naturally active components to control α-amylase/α-glucosidase activity is highly desired for preventing and managing type 2 diabetes. Rapeseed oil is rich in active phenolic compounds and seed oil is a major source of liposoluble inhibitors ...
Hui-Hui Liu, Chang Zheng, Ziliang Li, X. Xia, Dan-bin Jiang, Wen Wang, Ruiying Zhang, Xia Xiang   +7 more
semanticscholar   +1 more source

α-Glucosidase inhibitors isolated from medicinal plants [PDF]

, 2014
Objectiveα-Glucosidase inhibitors can be used as a new class of antidiabetic drug. By competitively inhibiting glycosidase activity, these inhibitors help to prevent the fast breakdown of sugars and thereby control the blood sugar level.
Feng, Fajin, Zhang, Wei, Kang, Wenyi, Yin, Zhenhua, Zhang, Yong   +4 more
core   +1 more source

Inhibitory Mechanism of Camellianin A against α-Glucosidase: In Vitro and Molecular Simulation Studies

Foods
α-Glucosidase is an important target for type II diabetes treatment, and the search for natural α-glucosidase inhibitors is currently a hot topic in functional food research.
Jinze Jia, Lu Bai, Yuzhen Chen, Benguo Liu   +3 more
doaj   +1 more source

Bound Polyphenols from Red Quinoa Prevailed over Free Polyphenols in Reducing Postprandial Blood Glucose Rises by Inhibiting α-Glucosidase Activity and Starch Digestion

Nutrients, 2022
Inhibiting α-glucosidase activity is important in controlling postprandial hyperglycemia and, thus, helping to manage type-2 diabetes mellitus (T2DM). In the present study, free polyphenols (FPE) and bound polyphenols (BPE) were extracted from red quinoa
Yu Zhang, B. Bai, Yu Yan, J. Liang, Xiao-Long Guan   +4 more
semanticscholar   +1 more source

Antioxidant and α-Glucosidase Inhibitory Compounds of Centella Asiatica [PDF]

, 2015
Centella asiatica, as known as Pegagan was previously reported to have anti-hyperglycemic effects in animal diabetic model rats. However, its α-glucosidase activity in vitro assay not yet reported. Our goal in this study is to isolate and identify active
Maryani, Faiza, Dewi, Rizna Triana
core   +1 more source

Analysis of the α-glucosidase sequence.

, 2013
A. Alignment of amino acid sequences of α-glucosidase from R. prolixus (AgluRp), Culex quinquefasciatus (AGluCulex, AGluCulex2, AGluCulex3), α-amylase from Aedes aegypti (AmAeds), maltase-like Agm2 from Anopheles gambiae (MaltaseAgm2), maltase 2 from ...
Ligia Souza Ferreira (370709), Gonçalo Apolinário de Souza-Filho (370713), Olga Lima Tavares Machado (370720), Carlos Peres Silva (370718), José Roberto da Silva (370708), Viviane Veiga do Nascimento (370719), Marilvia Dansa-Petretski (370723), Flávia Borges Mury (370707), Jayme Augusto de Souza-Neto (370715), Paulo Eduardo Martins Ribolla (370717), Marília Amorim Berbert-Molina (370721), Beatriz dos Santos Ferreira (370711)   +11 more
core   +1 more source

Synthesis of Novel Benzimidazole-Based Thiazole Derivatives as Multipotent Inhibitors of α-Amylase and α-Glucosidase: In Vitro Evaluation along with Molecular Docking Study

Molecules, 2022
In this study, hybrid analogs of benzimidazole containing a thiazole moiety (1–17) were afforded and then tested for their ability to inhibit α-amylase and α-glucosidase when compared to acarbose as a standard drug.
R. Hussain, S. Iqbal, Mazloom Shah, W. Rehman, Shoaib Khan, L. Rasheed, F. Rahim, A. Dera, Sana Kehili, E. Elkaeed, N. Awwad, Majed A. Bajaber, M. Alahmdi, Hamad Alrbyawi, H. Alsaab   +14 more
semanticscholar   +1 more source