Results 51 to 60 of about 2,753,652 (191)

DataSheet1_Responsive Fluorescent Coumarin–Cinnamic Acid Conjugates for α-Glucosidase Detection.DOCX

, 2022
α-Glucosidase is a potent drug target for treating type II diabetes mellitus. A great number of α-glucosidase inhibitors have been developed based on the molecular skeletons of bioactive natural products.
Dong Luo (428003), Xin Zhang (35492), Zhuang Xiong (335710), Xingyi Zeng (12965891), Xiaoying Li (147528), Yinghui Zhang (827119), Yi-Yu Zhen (12965888), Hongguang Li (829886)   +7 more
core   +1 more source

INHIBITORY EFFECT OF CURCUMIN INCORPORATED IN CHITOSAN NANOPARTICLE ON α-AMYLASE AND α-GLUCOSIDASE ACTIVITIES [PDF]

, 2022
Objective: This research was conducted to determine inhibition activity of curcumin nanoparticles against α-amylase and α-glucosidase enzymes.
APRILLIA, ADE Y, ANGGRAENI, RATNA, BUDIANI, SHAFA A, WULANDARI, WINDA T, TUSLINAH, LILIS   +4 more
core   +1 more source

Novel thiosemicarbazide-based β-carboline derivatives as α-glucosidase inhibitors: Synthesis and biological evaluation.

European journal of medicinal chemistry
In the quest for potent α-glucosidase inhibitors to combat diabetes, a series of novel thiosemicarbazide-based β-carboline derivatives (CTL1∼36) were synthesized and evaluated.
Bingwen Liang, Di Xiao, Shao-Hua Wang, Xue-Tao Xu   +3 more
semanticscholar   +1 more source

Inhibitory effects of a sulfated polysaccharide isolated from edible red alga Bangia fusco-purpurea on α-amylase and α-glucosidase

, 2019
In this study, a sulfated polysaccharide (BFP) was isolated from the edible red alga Bangia fusco-purpurea. Gel-filtration and thin layer chromatographically analyses suggested that BFP was a homogenous polysaccharide.
Zedong Jiang (4753668), Yan Liang (139654), Kenichi Yamaguchi (6885860), Yanbing Zhu (6869633), Hui Ni (1998790), Tianyuan Song (6885857), Tatsuya Oda (575177), Gang Yu (202259)   +7 more
core   +1 more source

Honokiol as an α-glucosidase inhibitor

Frontiers in Pharmacology
Honokiol, a naturally occurring compound from Magnolia obovata Thunb., has many biological activities, but its anti-α-glucosidase activity is still unclear. Therefore, we determined its inhibitory effects against α-glucosidase.
Hua Zhu, Xin Zhong
doaj   +1 more source

Bacillus subtilis JNUCC Isolated from Galchisokjeot: Draft Genome Sequence and α-glucosidase and Tyrosinase Inhibitory Activities

, 2020
Bacterial strains isolated from fermented foods are gaining significance as they are reported to have antibacterial, antioxidant, and anticancer properties.
Ji-Min Han, Sungmin Bae, Chang-Gu Hyun, Su Bin Hyun, Hoo-Dhon Byun   +4 more
core   +1 more source

Screening of α-Glucosidase Inhibitory Peptides from Tea Leaves using Ultrafiltration Affinity Combined with Liquid Chromatography-Mass Spectrometry and Molecular Docking Technology

Shipin gongye ke-ji, 2023
Objective: To screen for tea peptides with inhibitory activity against α-glucosidase. Methods: The response surface method was used to optimize the preparation process of tea peptides.
Lixia ZAN, Weiwei WANG, Wenyi ZHANG, Xinsheng LI, Xiaohua CHEN, Fei YAN, Jing FU   +6 more
doaj   +1 more source

Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting α-amylase, and α-glucosidase: synthesis, molecular docking, and ADMET studies

Journal of Enzyme Inhibition and Medicinal Chemistry
Inhibition of α-glucosidase and α-amylase are key tactics for managing blood glucose levels. Currently, stronger, and more accessible inhibitors are needed to treat diabetes.
Nirvana A. Gohar, E. Fayed, Y. Ammar, Ola A. Abu Ali, A. Ragab, A. Mahfoz, Moustafa S. Abusaif   +6 more
semanticscholar   +1 more source

New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with in silico studies

Frontiers in Chemistry, 2022
The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs showed a diverse range of activities having IC50 values between 0.80 ± 0.
Y. Khan, Shahid Iqbal, Mazloom Shah, A. Maalik, R. Hussain, Shoaib Khan, Imran H. Khan, R. Pashameah, Eman Alzahrani, Abd‐ElAziem Farouk, M. Alahmdi, H. S. M. Abd-Rabboh   +11 more
semanticscholar   +1 more source

Exploring synergistic inhibitory mechanisms of flavonoid mixtures on α-glucosidase by experimental analysis and molecular dynamics simulation.

Food Chemistry
The study was the first to evaluate the synergistic interaction of luteolin + quercetin, luteolin + 3-O-methylquercetin, and quercetin + 3-O-methylquercetin mixtures on α-glucosidase and the binding mechanisms were explored using both experimental and ...
Junkun Pan, Muhammad Nawaz, Jie-Chao Liu, Hui Liu, Zhen-Zhen Lv, Wen-Bo Yang, Zhong-Gao Jiao, Qiang Zhang   +7 more
semanticscholar   +1 more source