Results 31 to 40 of about 2,753,652 (191)

Synthesis and Molecular Docking Studies of Alkoxy- and Imidazole-Substituted Xanthones as α-Amylase and α-Glucosidase Inhibitors

open access: yesMolecules, 2023
Current antidiabetic drugs have severe side effects, which may be minimized by new selective molecules that strongly inhibit α-glucosidase and weakly inhibit α-amylase.
Dolores G. Aguila-Muñoz   +10 more
doaj   +1 more source

Docking Sulochrin and Its Derivative as α-Glucosidase Inhibitors of Saccharomyces cerevisiae

open access: yesIndonesian Journal of Chemistry, 2017
Sulochrin known has activity as inhibitors of α-glucosidase enzyme. Interaction of sulochrin to active site of α-glucosidase enzyme from S. cerevisiae has studied by docking method.
Wening Lestari   +3 more
doaj   +1 more source

Synthesis and Evaluation of Coumarin-Chalcone Derivatives as α-Glucosidase Inhibitors

open access: yesFrontiers in Chemistry, 2022
Coumarin and chalcone, two important kinds of natural product skeletons, both exhibit α-glucosidase inhibitory activity. In this work, coumarin-chalcone derivatives 3 (a∼v) were synthesized, and their α-glucosidase inhibitory activity was screened.
Chun-Mei Hu   +10 more
doaj   +1 more source

In vitro α-amylase and α-glucosidase inhibitory potential of Pleurotus ostreatus cv. Florida extract [PDF]

open access: yes, 2022
1016-1019Pleurotus ostreatus cv. Florida is one of the widely used edible mushroom. The polysaccharides from this mushrooms have been studied for antidiabetic potential; however, no efforts have been made to explore the potential of this mushroom to ...
Chourasia, Ayushi   +5 more
core   +1 more source

Inhibitory Kinetics of Cyanidin-3-O-glucoside against α-Amylase and α-Glucosidase [PDF]

open access: yes, 2023
The inhibitory mechanism of α-amylase and α-glucosidase by cyanidin-3-O-glucoside was investigated by ultrafiltration, high performance liquid chromatography (HPLC), enzyme kinetics, and molecular docking.
WANG Wei, CUI Yan, ZHENG Mingzhu, CAI Dan, LIU Jingsheng, LIU Meihong, LIU Huimin
core   +2 more sources

THE APPLICABILITY OF THE CRYSTAL STRUCTURE OF TERMOTOGA MARITIMA 4--GLUCANOTRANSFERASE AS THE TEMPLATE FOR SULOCHRIN AS -GLUCOSIDASE INHIBITORS

open access: yesIndonesian Journal of Chemistry, 2010
Interaction of sulochrin to active site of glucosidase enzyme of Termotoga maritime has been studied by employing docking method using Molecular Operating Environment (MOE), in comparison with those are reports of established inhibitor α-glucosidase such
Rizna Triana Dewi   +4 more
doaj   +1 more source

Chemical Constituents From the Aerial Part of Tiliacora triandra (Colebr.) Diels and Their α-Glucosidase and α-Amylase Inhibitory Activity

open access: yes, 2020
Two new fatty acid derivatives identified as 5,7-dihydroxy-6-oxoheptadecanoic acid (1) and ethyl-5,7-dihydroxy-6-oxooctadecanoate (2) together with four known compounds, ethyl linolenate (3), ethyl linoleate (4), ethyl pheophorbide A (5), and ...
Makinde, Emmanuel Ayobami   +4 more
core   +1 more source

Table_1_LC-Q-Orbitrap-MS/MS Characterization, Antioxidant Activity, and α-Glucosidase-Inhibiting Activity With In Silico Analysis of Extract From Clausena Indica (Datz.) Oliv Fruit Pericarps.DOC

open access: yes, 2021
Clausena indica (Datz.) Oliv fruit pericarps (CIOPs) is an important agro-industrial by-product rich in active components. In this article, the effects of traditional and green deep eutectic solvents (DESs) on the high-performance liquid chromatography ...
Zhaohui Li (442068)   +3 more
core   +1 more source

A method for in vivo evaluation of α-glucosidase inhibition using Drosophila

open access: yesMethodsX, 2023
The development of α-glucosidase inhibitors is essential for the prevention of type II diabetes. Previous research has investigated in vitro inhibition using isolated α-glucosidase, which may not accurately reflect physical processes.
Nattapong Wongchum   +4 more
doaj   +1 more source

Insight into the Inhibitory Mechanisms of Hesperidin on α-Glucosidase through Kinetics, Fluorescence Quenching, and Molecular Docking Studies

open access: yesFoods, 2023
The α-glucosidase inhibitor is of interest to researchers due to its association with type-II diabetes treatment by suppressing postprandial hyperglycemia. Hesperidin is a major flavonoid in orange fruit with diverse biological properties.
Kumaravel Kaliaperumal   +6 more
doaj   +1 more source

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