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Do the treatment selection factors emphasized in clinical guidelines—Chronic kidney disease, cardiovascular disease, and heart failure—contribute to the risk of urinary tract infections during the administration of sodium‐glucose cotransporter‐2 inhibitors?

Journal of Diabetes Investigation, Volume 17, Issue 9, Page 1489-1498, September 2026.
ABSTRACT Aims/Introduction Sodium‐glucose cotransporter‐2 inhibitors (SGLT2Is) are recommended in Japan for patients with cardiovascular disease (CVD), heart failure (HF), or chronic kidney disease (CKD) due to their organ‐protective effects, leading to increased use in high‐risk populations.
Takuma Koinuma, Manato Yoshida, Manabu Akazawa   +2 more
wiley   +1 more source

A Novel Peptide Derived from Sea Buckthorn Leaves: Enzymatic Preparation, Dual Inhibitory Activity Against α-Glucosidase and DPP-IV, and Its Molecular Mechanism. [PDF]

Foods
Qin X, Peng Y, Huang Y, Wang F, Guo J.
europepmc   +1 more source

An innovative strategy coupling cluster fraction with ultrafiltration UPLC-QTOF-MS/MS for screening α-glucosidase inhibitors from barley seedlings. [PDF]

Food Chem X
Lin C, Luo J, Wang S, Shen C, Zhang S, Liu Y, Song Z, Ma Y, Chen T, Li Y.   +9 more
europepmc   +1 more source

Enzyme Inhibition by Bioactive Compounds from Olive (<i>Olea europaea</i> L.) and Pomegranate (<i>Punica granatum</i> L.): Systematic Review of In Vitro Studies. [PDF]

Molecules
Vučina R, Drmač D, Rezić V, Čulum D, Kondža M.   +4 more
europepmc   +1 more source

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POTENTIAL INHIBITORS OF α-GLUCOSIDASE AND α-AMYLASE ENZYMES FROM LOCALLY AVAIALABLE FRUIT WASTES BY SOLID STATE FERMENTATION

Chemical and Natural Resources Engineering Journal (Formally known as Biological and Natural Resources Engineering Journal), 2019
ABSTRACT: A   therapeutic   approach   for   treating   diabetes   is   to   decrease   the   post-prandial hyperglycaemia. This is done by retarding the absorption of glucose through the inhibition of the carbohydrate hydrolyzing enzymes, α-amylase and α-glucosidase, in the digestive tract.
ANUMSIMA AHMAD BARKAT, Parveen Jamal, AZLIN SUHAIDA AZMI, IBRAHIM ALI NOORBACHA, DACHYAR ARBAIN, ZULKARNAIN MOHAMED IDRIS   +5 more
openaire   +1 more source

Development of inhibitors against lipase and α-glucosidase from derivatives of monascus pigment

FEMS Microbiology Letters, 2007
New derivatives of monascus pigment were produced during Monascus fermentation by the addition of unnatural amino acids, and the inhibitory activities of the derivatives against diet-related lipase and alpha-glucosidase were tested. Derivatives with penicillamine (H-Pen), cyclohexylalanine (H-Cha), butylglycine (L-t-Bg), and norleucine (H-Nle) showed ...
Jong Hoon, Kim, Hyun Jung, Kim, Hae Woong, Park, Sung Hun, Youn, Duck-Young, Choi, Chul Soo, Shin   +5 more
openaire   +2 more sources

ANTIDIABETIC ACTIVITY TEST OF BITTER GOURD EXTRACT (Momordica charantia) AS AN INHIBITOR OF α - GLUCOSIDASE ENZYME BY IN SILICO

2022
ABSTRACTDiabetes mellitus (DM) is a metabolic disorder that interferes with the metabolism of carbohydrates, fats, and proteins. This study aims to determine the types of bioactive compounds contained in bitter melon extract and to analyze interaction of targeted compounds against the α -glucosidase enzyme using the in silico approach.
Wowor, Kezya, Bodhi, Widdhi, Datu, Olvie, Windah, Axl   +3 more
openaire   +1 more source

Inhibitory Activity and Mechanism Investigation of Hypericin as a Novel α-Glucosidase Inhibitor

Molecules, 2021
Huilan Yue, Qi Dong, Hu Na
exaly  

New β-carboline derivatives as potential α-glucosidase inhibitor: Synthesis and biological activity evaluation

Journal of Molecular Structure, 2023
Jin Lin, Xu Xuetao, Zhuang Xiong
exaly  

A potent alpha-glucosidase inhibitor from Myristica cinnamomea King

Phytochemistry, 2016
Khalijah Awang, Marc Litaudon, Kok Hoong Leong   +2 more
exaly