Results 121 to 130 of about 91,213 (314)

Low-density lipoprotein receptor–related protein 1 mediates α-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson’s disease

Neural Regeneration Research
α-Synuclein accumulation and transmission are vital to the pathogenesis of Parkinson’s disease, although the mechanisms underlying misfolded α-synuclein accumulation and propagation have not been conclusively determined.
Hanjiang Luo, Caixia Peng, Chengli Wu, Chengwei Liu, Qinghua Li, Shun Yu, Jia Liu, Min Chen   +7 more
doaj   +1 more source

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease [PDF]

, 2017
The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role.
Alloatti, Matías, Cromberg, Lucas Eneas, Dimopoulos, Nicolás, Falzone, Tomas Luis, Marin Burgin, Antonia, Otero, Maria Gabriela, Pardi, María Belén, Pozo Devoto, Victorio Martin, Saez, Trinidad María de Los Milagros, Scassa, Maria Elida, Schinder, Alejandro Fabián, Sevlever, Gustavo, Stokin, Gorazd B.   +12 more
core   +1 more source

CD36‐Binding Amphiphilic Nanoparticles for Attenuation of α‐Synuclein‐Induced Microglial Activation

, 2022
Nanxia Zhao, Nicola L. Francis, Shuang Song, Vladyslav Kholodovych, Hannah Calvelli, Cody L. Hoop, Zhiping P. Pang, Jean Baum, Kathryn E. Uhrich, Prabhas V. Moghe   +9 more
openalex   +1 more source

Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson’s Disease [PDF]

, 2023
Tommi Kilpeläinen, Henri T. Pätsi, Reinis Svarcbahs, Ulrika Julku, Tony Eteläinen, Hengjing Cui, Samuli Auno, Nina Sipari, Susanna Norrbacka, Teppo O. Leino, Maria Jäntti, Timo T. Myöhänen, Erik A. A. Wallén   +12 more
openalex   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Elevated plasma levels of alpha-synuclein are dispensable for Parkinson’s disease pathology

npj Parkinson's Disease
Although α-synuclein levels are elevated in the blood plasma of Parkinson’s disease (PD) patients, it remains unclear whether blood-derived α-synuclein directly contributes to PD.
Jin-Young Jeong, Namsuk Kim, Yan Li, Doo-Jin Kim, Hyong Kyu Kim, Won-Jong Oh   +5 more
doaj   +1 more source

Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation [PDF]

, 2016
The Parkinson’s disease-associated protein α-synuclein exhibits significant conformational heterogeneity. Bacterially expressed α-synuclein is known to bind to copper, resulting in the formation of aggregation-prone compact conformations.
Dalton, Caroline, Mason, Rebecca, Paskins, Aimee, Smith, David   +3 more
core   +1 more source

Kisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro [PDF]

, 2022
Christopher A. Simon, Tomoko Soga, Nafees Ahemad, Saatheeyavaane Bhuvanendran, Ishwar S. Parhar   +4 more
openalex   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Intracellular Catalytic Photooxygenation of α‐Synuclein Amyloid

ChemistryEurope
The amyloid aggregation of α‐synuclein is a central pathological hallmark of various synucleinopathies, including Parkinson disease. Consequently, developing strategies to eliminate α‐synuclein amyloids represents a promising therapeutic approach.
Atsushi Iwai, Youhi Hwang, Hiroki Umeda, Taka Sawazaki, Ikumi Tomizawa, Maiko Ono, Makoto Higuchi, Youhei Sohma, Yukiko Hori, Taisuke Tomita, Harunobu Mitsunuma, Motomu Kanai   +11 more
doaj   +1 more source