Results 261 to 270 of about 91,213 (314)

Probing Early α‐Synuclein Oligomers: Insights Into Aggregation Pathways of NACore and preNAC Segments Probed by Trapped Ion‐Mobility Mass Spectrometry and Fluorescence Spectroscopy

PROTEOMICS, EarlyView.
ABSTRACT Misfolding and aggregation of α‐Synuclein (α‐Syn) play a central role in Parkinson's disease (PD), with oligomeric intermediates implicated as key toxic species. Here, we investigate the aggregation of two α‐Syn segments, the NACore (68GAVVTGVTAVA78, WT‐PD1) and the preNAC region (47GVVHGVATVA56, WT‐PD2), using high‐resolution trapped ion ...
Agathe Depraz Depland, Stephanie Mikromanolis, Iuliia Stroganova, Anouk M. Rijs   +3 more
wiley   +1 more source

Attenuating α-synuclein pathology in mice with in situ engineered astrocytes. [PDF]

Transl Neurodegener
Du XY, Zhou J, Zhu J, Zhang L, Lu S, Liang SY, Cui F, Zhang HH, Chen F, Jiao MY, Huang YR, Yu XL, Liu RT.   +12 more
europepmc   +1 more source

Associations of Vestibular Disorders With Risk of All‐Cause and Cause‐Specific Dementia: A Longitudinal Cohort Study in UK Biobank

Sensory Neuroscience, EarlyView.
ABSTRACT To explore associations of vestibular disorders with all‐cause and cause‐specific dementia and underlying biological mechanisms/neuroimaging changes. A population‐based cohort study of 406,348 UK Biobank participants was conducted. Inverse probability of treatment weighting (IPTW) balanced baseline covariates, and Cox proportional hazards ...
Xiaofei Li, Fan Jiang, Qiuyue Dong, Hao Chen, Hanbing Ji, Alimu Dayimu, Yifan Yu, Guorong Li, Na Li, Peipei Fu, Qi Jing, Maoli Duan, Hongkai Li, Shanquan Chen, Daogong Zhang, Haibo Wang   +15 more
wiley   +1 more source

The Effect of SARS-COV-2 Protein Fragments on the Dimerization of α-Synuclein. [PDF]

ACS Chem Neurosci
Coleman LM, Hansmann UHE.
europepmc   +1 more source

The Effects of Prolyl Oligopeptidase Inhibition in α-Synuclein Based Mouse Models of Parkinson's Disease

, 2020
openaire   +1 more source

New Hybrid Nanocomposite Films for Optical Diagnostics and Optical Temperature Sensing: Synergy Among α‐Synuclein, Gold and Upconverting Nanoparticles

Small, EarlyView.
Gold and upconverting nanoparticles coated with alpha‐synuclein were exploited to produce a quasi‐monolayer hybrid film. The film was then characterized, and its behaviour as a primary optical nano‐thermometer was studied. The film was also used in a proof‐of‐concept study of image‐based optical nanothermometry exploiting a home‐built up‐conversion ...
Emil Milan, Roberto Tira, Chiara Cressoni, Federico Antonio Giacomazzi, Patrizia Canton, Michael Assfalg, Adolfo Speghini   +6 more
wiley   +1 more source

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, EarlyView.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source

α-synuclein fibrils per se but not α-synuclein seeded aggregation causes mitochondrial dysfunction and cell death in human neurons. [PDF]

Redox Biol
Angelova PR, Esteras N, Evans J, Kostic M, Melki R, Prehn JHM, Gandhi S, Abramov AY.   +7 more
europepmc   +1 more source