Results 241 to 250 of about 83,002 (289)

Revealing the invisible: a new imaging paradigm for α-synuclein pathology in Parkinson's disease. [PDF]

Front Radiol
Meng J, Li X.
europepmc   +1 more source

The role of axonopathy in Parkinson\u27s disease [PDF]

, 2010
O’Malley, Karen L
core   +1 more source

SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism

Cell Proliferation, EarlyView.
This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).
Yang Yang, Juan He, Jing Zheng, Bing Shao, Lixin Shi, Miao Zhang   +5 more
wiley   +1 more source

The cross-linking activity of transglutaminase 2 drives α-Synuclein pathology in synucleinopathy models. [PDF]

Proc Natl Acad Sci U S A
Hassanzadeh K, Liu J, Zhang J, Tabari MA, Maddila S, Mouradian MM.   +5 more
europepmc   +1 more source

ACTH suppression and adverse effects of cabergoline in horses with pituitary pars intermedia dysfunction

Equine Veterinary Education, EarlyView.
Summary Background The diagnosis and management of pituitary pars intermedia dysfunction (PPID) in horses includes evaluating abnormal plasma concentrations of adrenocorticotrophic hormone (ACTH). Treatment commonly includes the oral dopamine agonist pergolide mesylate, which suppresses the pathologic overproduction of ACTH.
A. Bracken, H. Tyra, M. Vetter, K. Kiger, S. Rao, L. Bass   +5 more
wiley   +1 more source

Competing chaperone pathways in α-synuclein disaggregation and aggregation dynamics. [PDF]

Protein Sci
Auld NK, McMahon S, Marzano NR, van Oijen AM, Ecroyd H.   +4 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Pathogenic mechanism underlying parkinsonism induced by neurotoxicants (MPTP and 6-hydroxydopamine) and α-synuclein: a unifying hypothesis. [PDF]

J Mol Cell Biol
Zhu BT.
europepmc   +1 more source